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Cryptococcus neoformans protein triggers murine anticandidal activity.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Italy and the United States have identified a novel method for inducing anticandidal immune activity.
"We previously demonstrated that mannoprotein (MP) from Cryptococcus neoformans (CnMP) stimulates interleukin-12 production by human monocytes, thus fostering a T-helper type 1 (Th1) protective anticryptococcal response," explained Donatella Pietrella and colleagues at the University of Perugia in Perugia and Istituto Superiore di Sanita in Rome, Italy, and Georgia State University in Atlanta.
Further experiments revealed that CnMP also triggers Th1 activity against Candida albicans, Pietrella and coauthors reported.
Mice inoculated with CnMP showed delayed-type hypersensitivity (DTH) reactions to C. albicans MP (CaMP), the researchers said. Moreover, helper and cytotoxic T cells from the spleens of CnMP-treated mice produced gamma interferon after CaMP exposure.
Immunization with CnMP also conferred partial protection against C. albicans infection, study data showed. CnMP-treated animals had reduced renal levels of the fungus, and survived longer after C. albicans infection compared with control mice.
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Source: HighBeam Research, Cryptococcus neoformans protein triggers murine anticandidal activity.