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Soybeans could offer edible alternative to injected vaccine.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - For years, scientists have strived to develop vaccines that could be eaten in vegetables. One of the latest studies indicates soybeans could some day be conduits for hepatitis B virus (HBV) vaccine.
Scientists at Cornell University in Ithaca, New York have explored hepatitis B surface antigen (HBsAg) processing in soybean and tobacco cell batch cultures.
"The HBsAg was chosen for study because it undergoes substantial and complex post-translational modifications, which are necessary for immunogenicity," said Mark L. Smith and colleagues.
Smith's team discovered that most HBV antigens produced by the plant cells were membrane associated and remained localized within the cell. Soybean cells yielded higher titers than tobacco cells in the batch cultures.
"For soybean cells, electron microscopy and immunolocalization demonstrated that all the HBsAg was localized to the endoplasmic reticulum (ER) and provoked dilation and proliferation of the ER network," Smith and coauthors reported.
Plant cells produced significant concentrations of HBsAg protein (p24[superscript]S) dimers, but many antigen ...
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