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Oligonucleotide-based topical immunotherapy against HSV-2 has promise.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Vaccinologists at the University of Texas say immunostimulatory sequence-containing oligonucleotides may have application as treatment for genital herpes.
"Synthetic oligonucleotides containing CpG motifs in specific sequence contexts have been shown to induce potent immune responses. We have evaluated mucosal administration of two immunostimulatory sequence (ISS)-containing phosphorothioate-stabilized oligonucleotides for antiherpetic efficacy in animal models," stated R.B. Pyles and colleagues.
"The ISS oligonucleotides, suspended in phosphate-buffered saline, were tested in mouse and guinea pig vaginal models of herpes simplex virus type 2 (HSV-2) infection. For comparison, groups of untreated, non-ISS oligonucleotide-treated, and acyclovir-treated animals also were monitored," explained the researchers.
Their "results indicated that vaginal epithelial application of ISS (up to 6 hours after viral inoculation) with mice lethally challenged with HSV-2 delayed disease onset and reduced the number of animals that developed signs of disease (p=0.003). ISS application significantly increased survival rates over those of controls (p=0.0014)," reported Pyles' group.
They said that "[t]he ISS also impacted an established infection in the guinea pig model of HSV-2 disease. A single administration of ISS (21 days after viral inoculation) significantly reduced the frequency and severity of HSV-2 lesions compared to results with non-ISS ...
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Source: HighBeam Research, Oligonucleotide-based topical immunotherapy against HSV-2 has promise.