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Tumor cell lysate-pulsed DC effective for T-cell lymphoma immunotherapy.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemical adjuvant (QS-21) induces a protective, Id-specific immune response against the murine T-cell lymphoma, C6VL. However, Id-based immunotherapy of C6VL has not demonstrated therapeutic efficacy in tumor-bearing mice."
University of Michigan immunologists "report that C6VL lysate-pulsed dendritic cells (C6VL-DC) vaccines display enhanced efficacy in both the prevention and the therapy of T-cell lymphoma compared with TCR Id:KLH with QS-21 vaccines."
According to E. Gatza and colleagues, "C6VL-DC vaccines stimulated potent tumor-specific immunity that protected mice against lethal challenge with C6VL and significantly enhanced the survival of tumor-bearing mice.
"Tumor-specific proliferation and secretion of IFN-gamma indicative of a Th1-type immune response were observed upon ex vivo stimulation of vaccine-primed lymph node cells. Adoptive transfer of immune T-cell-enriched lymphocytes was sufficient to protect naive recipients from lethal tumor challenge."
They also found that "CD8+ T cells were absolutely required for tumor protection."
"Although C6VL-DC ...
- Tumor cell lysate-pulsed DC effective for T-cell lymphoma immunotherapy.
- Newspaper article from: Immunotherapy Weekly January 8, 2003 700+ words
...hemocyanin (KLH) (TCR Id:KLH) and injected...the murine T-cell lymphoma, C6VL. However...therapy of T-cell lymphoma compared with TCR Id:KLH with QS...effective than TCR Id protein vaccines...immunotherapy of T-cell lymphoma. J Immunol...
- Tumor cell lysate-pulsed DC effective for T-cell lymphoma...
- Newspaper article from: Cancer Weekly January 7, 2003 700+ words
...hemocyanin (KLH) (TCR Id:KLH) and injected...the murine T-cell lymphoma, C6VL. However...therapy of T-cell lymphoma compared with TCR Id:KLH with QS...effective than TCR Id protein vaccines...immunotherapy of T-cell lymphoma. J Immunol...
- Tumor cell-pulsed dendritic cells extend survival of mice with T cell lymphoma.
- Newspaper article from: Cancer Weekly January 14, 2003 700+ words
...with lysates of murine C6VL T cell lymphoma cells protected mice against...of the T-cell receptor (TCR) Id protein and keyhole limpet...cells are more effective than TCR Id protein vaccines for active...pulsed with murine C6VL T cell lymphoma cell lysate protected ...
- Tumor cell-pulsed dendritic cells extend survival of mice with T cell...
- Newspaper article from: Vaccine Weekly January 15, 2003 700+ words
...with lysates of murine C6VL T cell lymphoma cells protected mice against...of the T-cell receptor (TCR) Id protein and keyhole limpet...cells are more effective than TCR Id protein vaccines for active...pulsed with murine C6VL T cell lymphoma cell lysate protected ...
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- Newspaper article from: Blood Weekly February 5, 2009 700+ words
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- Newspaper article from: Blood Weekly November 6, 2008 700+ words
...lymphoma, about 35% of diffuse large B-cell lymphoma, 23% of chronic lymphocytic leukemia...Paulo, Brazil report (see also Large-Cell Lymphoma). "Anaplastic large cell lymphoma is a rare disease that accounts for less...
- New data from M. Rodriguez-Justo et al illuminate research in t-cell lymphoma...
- Newspaper article from: Blood Weekly June 25, 2009 700+ words
...discuss in 'Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres...cell markers' new findings in t-cell lymphoma. According to a study from London...Kingdom, "Angioimmunoblastic T-cell lymphoma is an aggressive peripheral T-cell...