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Recombinant E. coli vaccine promotes MHC class I-dependent antigen presentation.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Cancer researchers in England "have examined the potential of recombinant Escherichia coli expressing listeriolysin 0 (LL0) to deliver tumor antigens to dendritic cells (DCs) for cancer immunotherapy."
"Using OVA [ovalbumin] as a model tumor antigen," K.J. Radford and colleagues, Hammersmith Hospital, were able to show "in murine DCs that E. coli expressing cytoplasmic LL0 and OVA proteins can deliver the OVA K-b-restricted epitope SIINFEKL for MHC class I presentation."
"In contrast," they said, "when E. coli expressing OVA alone were used, MHC class II presentation of the OVA 323-339 I-A(b)-restricted peptide was predominant when injected in vivo.
"DCs pulsed with E. coli expressing LL0 and OVA induced production of cytotoxic T-lymphocytes capable of lysing an OVA-expressing melanoma cell line (B16-OVA) and resulted in suppression of tumor growth following challenge with B16-OVA," wrote Radford and associates.
"Immunization of mice by direct injection of E. coli LL0/OVA provided a more potent antitumor response, resulting in complete protection in 75% of mice. Injection of live bacteria was ...
- New cancer gene therapy findings from University of Saskatchewan described.
- Newspaper article from: Cancer Gene Therapy Week June 1, 2009 700+ words
...TERT)mTNF-alpha gene therapy by intratumoral injection...established BL6-10(OVA) tumors in 4/10 tumor...bearing mice, and induces OVA-specific CD8(+) T...Saskatchewan (see also Cancer Gene Therapy). The researchers concluded...
- Researchers from University of Saskatchewan report on findings in cancer gene...
- Newspaper article from: Cancer Gene Therapy Week April 27, 2009 700+ words
...established ovalbumin (OVA)-expressing murine B16 melanoma (BL6-10(OVA)) (6 mm in diameter...report (see also Cancer Gene Therapy). "We demonstrated...bearing mice, and induces OVA-specific CD8...TERT)mTNF-alpha gene therapy may be very useful in...
- Study data from University of North Carolina, Gene Therapy Center provide new...
- Newspaper article from: Blood Weekly August 27, 2009 700+ words
...administration. Most importantly, these OVA-specific CTLs decreased AAT...in mice treated with AAV2-OVA/AAT vector that followed a...kinetics of AAV2 transduction in OVA-immunized mice. These results...University of North Carolina, Gene Therapy Center (see also Clinical Trial...
- Interferon-gamma- and Interleukin-4-Targeted Gene Therapy for Atopic Allergic...
- Newspaper article from: Gene Therapy Weekly September 6, 1999 700+ words
...Interleukin-4-Targeted Gene Therapy for Atopic Allergic Disease...chosen as targets for gene therapy. Anti-allergic activity...group; the ovalbumin (OVA) group; the IFN-gamma...injected with saline and the OVA group with OVA-alum...
- Research from Pohang University of Science and Technology provides new data on...
- Newspaper article from: Cancer Gene Therapy Week November 17, 2008 700+ words
...report (see also Gene Therapy). "In a prophylactic...rAd/ovalbumin (OVA) and rAd/IL-23N220L enhanced OVA-specific CD8...subsequent challenge of OVA-expressing E.G7...their study in Cancer Gene Therapy (Adenovirus-mediated...
- Gene Therapy: Pharmaceutical Alteration of the Human Genome.
- Magazine article from: MedSurg Nursing Capriotti, Teri October 1, 2001 700+ words
...Basic Concepts of Gene Therapy The overall goal of gene therapy is to improve an individual...become a sperm or ovum). In the United States, only somatic cell gene therapy has been approved...cells (sperm and ova) alter the genetic...
- Studies from F. Arce et al further understanding of gene therapy.
- Newspaper article from: Gene Therapy Weekly November 5, 2009 700+ words
...Expression of ovalbumin (OVA) in the LV reduced the number...proliferation and activation of OVA-specific CD8(+) T cells...maintained cytolytic activity against OVA-pulsed targets," wrote F. Arce and colleagues (see also Gene Therapy). The researchers concluded...
- Recent studies by D. Hoangle and co-authors add new data to gene therapy...
- Newspaper article from: Cancer Gene Therapy Week May 4, 2009 700+ words
...Kunjin replicon system for gene therapy," researchers in Brisbane...Australia report (see also Gene Therapy). "Intra-tumoral...colon carcinoma and B16-OVA melanomas. Regression...system for intra-tumoral gene therapy applications." Hoangle...