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Pancreatic cancer research should focus on antigen presentation, targeted drug delivery.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Mistletoe lectins were adjuvants as powerful as the cholera toxin when administered with herpes simplex virus glycoprotein D2 (gD2) nasotracheally, according to a report in the journal, Immunology.
Lectins are molecules of nonimmune origin that can act in a manner similar to antibodies by agglutinating specific cells or precipitating certain glycoconjugates.
Ed C. Lavelle, at Trinity College in Dublin, and colleagues in the United Kingdom, United States, and Germany, isolated three type 2 ribosome-inactivating proteins (RIPs) from the European mistletoe, Viscum album. The mistletoe lectins (MLI, MLII and MLIII) were individually coadministered with gD2 to mice and the immune responses compared with those generated by gD2 coadministered with the cholera toxin (CT).
"All three mistletoe lectins were potent mucosal adjuvants," reported Lavelle and his associates (Mistletoe lectins enhance immune responses to intranasally coadministered herpes simplex virus glycoprotein D2. Immunology, 2002;107(2):268-274).
Compared with antigen delivery alone, antigen plus MLI, MLII or MLIII stimulated significantly higher levels of antigen-specific IgA and IgG antibodies. The increases in antibody levels were comparable with those seen with codelivery of gD2 and CT. MLI also caused the proliferation of gD2-specific ...
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...with ML I B chain. The recognition of glycoconjugates by mistletoe lectins is even more complex and also controlled by their own glycan...preparations used therapeutically. Keywords: Glycosylation; Mistletoe lectins; Glycan motifs; Biomolecular interaction analysis; Biological...
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Source: HighBeam Research, Pancreatic cancer research should focus on antigen presentation,...