AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Modified rabies virus vectors safe, effective.
2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Novel rabies virus (RV)-based vaccines can safely protect animals against HIV infection, researchers in the United States report.
RV-based vectors "show great promise as vaccines against other viral diseases such as human immunodeficiency virus type 1 (HIV-1) infection and hepatitis C, but a low residual pathogenicity remains a concern for their use," explained James P. McGettigan and colleagues at Thomas Jefferson University in Philadelphia.
A series of second-generation RV-based vaccines have been rendered apathogenic without sacrificing their antiviral efficacy, McGettigan and coauthors said.
The researchers tested a series of modifications to the SPBN RV vaccine vector, which was designed to express the HIV Gag protein. They replaced an arginine residue with glutamic acid at position 333 in the RV glycoprotein (G) and/or deleted 43 amino acids from RV G's cytoplasmic domain, according to the report.
SPBN-Gag with one or both of these modifications was apathogenic after peripheral or cranial administration in mice, study data showed. The altered vector induced "robust" cellular responses against HIV Gag, comparable in ...
- Modified rabies virus vectors safe, effective.
- Newspaper article from: AIDS Weekly January 6, 2003 700+ words
...medical writer - Novel rabies virus (RV)-based vaccines...designed to express the HIV Gag protein. They replaced...cellular responses against HIV Gag, comparable in potency...Second-generation rabies virus-based vaccine vectors...
- New findings from Institute Pasteur describe advances in rabies virus cell...
- Newspaper article from: Virus Weekly November 10, 2009 700+ words
Fresh data on rabies virus are presented in the report 'A novel animal-component-free medium for rabies virus production in Vero cells grown on...work. Kinetics of cell growth and rabies virus (strain LP 2061) production were...
- Findings from Y.Z. Zhang and co-authors provide new insights into rabies virus.
- Newspaper article from: Virus Weekly August 12, 2008 700+ words
...healthy animals are potential carriers of rabies virus in China, 153 domestic dogs were collected...for 6 months. Initially, findings of rabies virus antigen in the saliva of 15 dogs by...the ELISA test alone, detection of rabies virus antigen in saliva of some animals was...
- Reports from G. Sato and co-researchers add new data to research in rabies...
- Newspaper article from: Virus Weekly March 10, 2009 700+ words
...position 333 on the glycoprotein of the rabies virus is considered necessary for virulence...only been found in fixed strains of rabies virus. In this study, the authors found...333Q substitutions at this position in rabies virus street strains isolated from non-hematophagous...
- New rabies virus study findings have been reported by researchers at Trent...
- Newspaper article from: Virus Weekly October 14, 2008 700+ words
...genome of a mid-Atlantic raccoon strain rabies virus (RRV) isolated in Canada was sequenced...is the second North American wildlife rabies virus isolate to be fully characterized...Peterborough, Canada report (see also Rabies Virus). "The nucleotide sequence identity...
- Rabies virus in raccoons, Ohio, 2004.(DISPATCHES)
- Magazine article from: Emerging Infectious Diseases Henderson, J. Caroline Biek, Roman Hanlon, Cathleen A. O'Dee, Scott Real, Leslie A. April 1, 2008 700+ words
In 2004, the raccoon rabies virus variant emerged in Ohio beyond...containment and elimination of the rabies virus variants associated with this species...goal of eliminating particular rabies virus variants from their respective...
- New rabies virus research from M.A. Neubaum and colleagues discussed.
- Newspaper article from: Virus Weekly August 19, 2008 700+ words
...The literature supports that unique rabies virus (RABV) variants are often compartmentalized...the United States report (see also Rabies Virus). "RABV associated with this species...analysis of correspondence between unique rabies virus variants and divergent big brown bat...
- From rabies virus to anti-HIV vaccine.(Brief Article)
- Magazine article from: Science News N.S. April 8, 2000 700+ words
...University in Philadelphia reconstructed a rabies virus to the point that it no longer caused...mice. Five others received weakened rabies virus without the gp 160-production capability...to slay the cells they invade. This rabies virus doesn't kill the cells it takes over...
Source: HighBeam Research, Modified rabies virus vectors safe, effective.