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Synthesized nucleotides can downregulate targeted genes in embryos.(genetic expression regulation)
2003 JAN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Genetic expression can be halted in preimplanted embryos with morpholino antisense oligonucleotides (MOs), researchers in Canada have reported.
"MOs act by blocking translation of their target gene products and are effective tools for downregulating gene expression," explained L.S. Siddall and colleagues, University of Western Ontario, London, Ontario, Canada.
MOs could potentially be used for eradicating certain genes in mammalian embryos while they undergo preimplantation development. The team used either of two delivery agents, Lipofectin or Lysolecithin, to convey alpha-catenin MOs or control MOs to murine embryos.
They performed several experiments to compare the effectiveness of MOs in two-cell and eight-cell embryos when delivered at various concentrations over different lengths of time (Targeting gene expression in the preimplantation mouse embryo using morpholino antisense oligonucleotides. Molecular Reproduction and Development, December 2002;63(4):413-421)
When two-cell embryos were continuously ...
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Source: HighBeam Research, Synthesized nucleotides can downregulate targeted genes in...