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Intranasal immunization with sperm-specific antigen has vaccine potential.(contraceptive vaccine)
2003 JAN 2 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that an intranasal vaccine they developed elicited immunoglobulin A (IgA) and IgG antibodies in the sera and vaginal secretions of mice.
"The common mucosal immune system (CMIS) has developed as a barrier for the numerous encounters between the host and various pathogens. It is possible to exploit this system to induce secretion of IgA antibody which inhibits sperm penetration in the female genital tract," stated A. Hasegawa and colleagues, Hyogo Medical University.
They investigated "the immunogenicity of a human sperm surface antigen (CD52) introduced by intranasal immunization ... with a view to developing a contraceptive vaccine."
"A synthetic peptide corresponding to CD52 core peptide (GQNDTSQTSSPS) was prepared and conjugated with diphtheria toxoid (DT) as a carrier protein. The immunogen was given to mice with DOTAP: cholesterol liposome adjuvant intranasally, followed by determination of Ig and IgA class antibody levels in the sera and vaginal washes."
The researchers reported that "CD52 core peptide elicited IgA class as well as Ig antibodies both in the sera and vaginal secretions after intranasal immunization. An additional nasal inoculation after decrease of the antibody titer raised the antibody level ...
- Intranasal immunization with sperm-specific antigen has vaccine potential.
- Newspaper article from: Vaccine Weekly January 1, 2003 700+ words
...introduced by intranasal immunization ... with...developing a contraceptive vaccine." "A synthetic...secretions after intranasal immunization. An additional...genital tract. Intranasal immunization of a sperm...and easy contraceptive vaccine," concluded...
- Intranasal vaccine generates antibody reaction in the genital...
- Magazine article from: Women's Health Weekly January 16, 2003 700+ words
...female genital tract," said Hasegawa and associates. "Intranasal immunization of a sperm-specific antigen would be a promising regimen for a safe and easy contraceptive vaccine." The corresponding author for this study is K. Koyama...
- ORTHO PHARMACEUTICAL LICENSES CONTRACEPTIVE VACCINE FROM VIRGINIA'S CENTER FOR...
- Press release article from: PR Newswire January 20, 1992 700+ words
...PHARMACEUTICAL LICENSES CONTRACEPTIVE VACCINE FROM VIRGINIA'S CENTER...licensing agreement for a contraceptive vaccine for women that prevents...administration suggest that a contraceptive vaccine would offer effective...
- ORTHO PHARMACEUTICAL LICENSES CONTRACEPTIVE VACCINE FROM VIRGINIA'S CENTER FOR...
- Press release article from: PR Newswire January 21, 1992 700+ words
...PHARMACEUTICAL LICENSES CONTRACEPTIVE VACCINE FROM VIRGINIA'S CENTER...licensing agreement for a contraceptive vaccine for women that prevents...administration suggest that a contraceptive vaccine would offer effective...
- Zonagen Signs Collaborative Option Agreement With American Home Products On...
- Press release article from: Business Wire December 13, 2000 700+ words
...effectiveness of Zonagen's human contraceptive vaccine using Zonagen's proprietary antigen...approved. Zonagen believes that a contraceptive vaccine for humans may be derived from...development of an effective human contraceptive vaccine has been ten years in the making...
- Published Zonagen Data Heralds Potential for New Contraceptive Vaccine.
- Press release article from: Business Wire September 18, 2000 700+ words
...the potential of the Company's contraceptive vaccine. The publication reported results...The Company has been working on a contraceptive vaccine targeting the zona pellucida since...step closer to the goal of a human contraceptive vaccine." "We are pleased with the progress...
- Contraceptive vaccine shows promise in animals, scientist says.
- Newspaper article from: St. Louis Post-Dispatch (St. Louis, MO) July 24, 2005 700+ words
...the antibodies to attack only the sperm or egg. If the target protein exists anywhere else in the body, a contraceptive vaccine would cause the body's immune system to attack itself. Naz says only a handful of unique sperm or egg proteins...
- IMMUCON - Male reversible contraceptive vaccine technology now patented in the...
- Press release article from: PR Newswire July 12, 1999 700+ words
...binding protein acquired following the spermatogenesis. According to IMMUCON, the market for a male reversible contraceptive vaccine with a 12 month efficacy period, is approximately 850 million US$. Current contraceptive methods are still...
Source: HighBeam Research, Intranasal immunization with sperm-specific antigen has vaccine...