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Vascular growth factor a prerequisite for normal uterine implantation.(possible infertility cause)
2003 JAN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Low levels of vascular endothelial growth factor (VEGF) could be responsible for some cases of infertility, researchers have determined.
Working with estrogen, VEGF makes the uterine environment amenable to implantation, according to a research team at the University of Maryland School of Medicine in Baltimore, Maryland.
Microvascular permeability fosters the formation of uterine edema. This edema accompanies endometrial remodeling, enabling embryos to thrive after implantation. Researchers believe a continuum that begins with the angiogenic protein VEGF is required for estrogen-induced implantation.
"Estrogen-induced uterine edema is immediately preceded by an increase in the expression of VEGF, a potent stimulator of microvascular permeability," L. Christie Rockwell and colleagues remarked in Biology of Reproduction.
Rockwell's team conducted a series of rodent model experiments that showed exactly how VEGF influences implantation. In one experiment, researchers treated immature female rats with anti-VEGF serum or normal rabbit serum before giving them estradiol, a potent form of estrogen.
"Rats treated with estradiol alone showed a 57% increase in uterine wet weight at 6 hours compared with controls," researchers stated. "Injection of 200 or 300 microliters of VEGF antiserum reduced the response to only 20% and 10% above controls, ...
- Growth factor receptor inhibits uterine edema stemming from estrogen.
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...soluble receptor for vascular endothelial growth factor can control estrogen-stimulated edema...antagonist of vascular endothelial growth factor A (VEGF-A), sflt-1 (soluble...Endocrinology (Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial...
- Vascular growth factor a prerequisite for normal uterine implantation.
- Newspaper article from: Angiogenesis Weekly January 3, 2003 700+ words
...vascular endothelial growth factor/vascular permeability...estrogen-induced uterine edema and implantation...study include: * Uterine edema and endometrial...vascular endothelial growth factor (VEGF) levels...formation of uterine edema, which is required...
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Source: HighBeam Research, Vascular growth factor a prerequisite for normal uterine...