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TETRAMUNE/PnCV combination is safe, immunogenic.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- A recent study reports that the combination of a 9-valent pneumococcal polysaccharide/protein conjugate vaccine and TETRAMUNE - the diphtheria, tetanus toxoid, cell pertussis and Haemophilus influenzae type b vaccine - is safe and immunogenic in Gambian babies.
"Pneumococcal polysaccharide/protein conjugate vaccines (PnCV) are immunogenic and effective in infancy. However, an addition to the nine currently recommended vaccine injections during the first year of life of African children may be a deterrent to participation in a PnCV program. Thus we have evaluated the safety and immunogenicity of a 9-valent PnCV (Wyeth Lederle Pediatrics and Vaccines) mixed with...TETRAMUNE," wrote S.K. Obaro and colleagues, University of London.
"Healthy Gambian infants were randomized at the age of two months to receive three doses one month apart of either (1) placebo reconstituted in TETRAMUNE in the right thigh (control) or (2) PnCV in the left thigh and TETRAMUNE in the right thigh (separate) or (3) PnCV reconstituted in TETRAMUNE as a single injection in the right thigh (combined). The vaccines were given together with routine Expanded Program on Immunization vaccines. Adverse reactions were recorded after vaccination, and antibody concentrations were measured by enzyme-linked immunosorbent assays," the researchers said.
They reported that "local induration and tenderness were observed more commonly at the site of injection of TETRAMUNE than at the site of injection with PnCV after each dose of vaccination. Swelling at the site of injection was encountered more frequently at the site of administration of TETRAMUNE than at the site of administration PnCV (p
"Although most mothers reported that the babies ''felt hot'' 24 hours after each injection, febrile reactions (temperature, greater than or equal to 38 degrees C) were infrequent and resolved with antipyretics," said Obaro and colleagues.
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