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Adjuvant protects against bacterial exotoxin and influenza virus infection.

Vaccine Weekly

| January 01, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "A novel nontoxic form of chimeric mucosal adjuvant that combines the A subunit of mutant cholera toxin E112K with the pentameric B subunit of heat-labile enterotoxin from enterotoxigenic Escherichia coli was constructed by use of the Brevibacillus choshinensis expression system (mCTA/LTB)," reported immunologists in Japan.

The researchers said, "Nasal immunization of mice with tetanus toxoid (TT) plus mCTA/LTB elicited significant TT-specific immunoglobulin A responses in mucosal compartments and induced high serum immunoglobulin G and immunoglobulin A anti-TT antibody responses. Although TT plus native CT induced high total and TT-specific immunoglobulin E responses, use of the chimera molecule as mucosal adjuvant did not. Furthermore, all mice immunized with TT plus mCTA/LTB were protected from lethal systemic challenge with tetanus toxin."

M.N. Kweon and colleagues said, "Importantly, the mice were completely protected from influenza virus infection after nasal immunization with inactivated influenza vaccine ...

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Source: HighBeam Research, Adjuvant protects against bacterial exotoxin and influenza virus...

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