AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Intranasal dLOS-CRM vaccine against Moraxella catarrhalis studied.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- U.S. National Institutes of Health researchers investigated the effect of intranasal immunization with a detoxified-lipooligosaccharide-cross-reactive mutant of diphtheria toxin (dLOS-CRM) vaccine candidate on pulmonary clearance following an aerosol challenge of mice with Moraxella catarrhalis."
"Moraxella catarrhalis is an important human mucosal pathogen," noted X.N. Jiao and colleagues.
"Intranasal immunization with dLOS-CRM plus cholera toxin induced a significantly dose-dependent increase of immunoglobulin A (IgA) and IgG in the nasal wash, lung lavage fluid, saliva, and fecal extract [of the mice]," the researchers reported.
"In addition, serum IgG, IgM, and IgA against LOS of M. catarrhalis were detected. LOS-specific antibody-forming cells were found in the nasal passages, spleens, nasally associated lymphoid tissues, cervical lymph nodes, lungs, and Peyer's patches using an enzyme-linked immunospot assay.
"The dLOS-CRM vaccine induced a significant bacterial clearance (70% to 90%) of both homologous and heterologous strains in the lungs compared to that observed in the controls (p
"Intriguingly," they said, "intranasal immunization with dLOS-CRM showed a higher level of bacterial clearance compared with subcutaneous injections with dLOS-CRM."
"These data ...
- Moraxella catarrhalis protein is adhesin for human lung cells.
- Newspaper article from: Drug Week June 4, 2004 700+ words
...amp; NewsRx.net) -- The Moraxella catarrhalis porin-like outer membrane protein...membrane protein CD (OMPCD) of Moraxella catarrhalis is an outer membrane protein with...in Infection and Immunity (The Moraxella catarrhalis porin-like outer membrane protein...
- Patent No. 7,557,185 Issued on July 7, Assigned to Cortecs for Moraxella...
- News wire article from: US Fed News Service, Including US State News July 9, 2009 700+ words
...9 -- Allan W. Cripps of Nicholls, Australia, and Jennelle Kyd of McKellar, Australia, have developed a moraxella catarrhalis proteins. The inventors were issued U.S. Patent No. 7,557,185 on July 7. The patent has been assigned...
- Intranasal immunization with sperm-specific antigen has vaccine...
- Magazine article from: Women's Health Weekly January 2, 2003 700+ words
...antigen (CD52) introduced by intranasal immunization ... with a view to developing...sera and vaginal secretions after intranasal immunization. An additional nasal inoculation...in the female genital tract. Intranasal immunization of a sperm-specific antigen...
- Intranasal immunization with sperm-specific antigen has vaccine potential.
- Newspaper article from: Vaccine Weekly January 1, 2003 700+ words
...antigen (CD52) introduced by intranasal immunization ... with a view to developing...sera and vaginal secretions after intranasal immunization. An additional nasal inoculation...in the female genital tract. Intranasal immunization of a sperm-specific antigen...
- CIPRO(R) Receives FDA Clearance to Treat Acute Sinusitis
- Press release article from: PR Newswire June 5, 1997 700+ words
...pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. The recommended adult dosage...such as Haemophilus influenzae and Moraxella catarrhalis. In light of these challenges...pneumoniae, Haemophilus influenzae and Moraxella catarrhalis -- are becoming increasingly resistant...
- Rhone-Poulenc Rorer Launches New Anti-Infective ZAGAM(R) in U.S.
- Press release article from: PR Newswire May 19, 1997 700+ words
...Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae or Streptococcus...pathogens Haemophilus influenzae and Moraxella catarrhalis, although clinical efficacy has...Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae or Streptococcus...
- Clinical Pharmacokinetics Laboratory Shows Bugs Among Us Wage War on U.S....
- Press release article from: PR Newswire May 19, 1997 700+ words
...pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae or Streptococcus...influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus...Haemophilus influenzae -- Moraxella catarrhalis The interim results represent ...
- Avelox(R) (Moxifloxacin HCI) Study Reports Faster Symptom Relief and Earlier...
- Press release article from: PR Newswire November 1, 2004 700+ words
...strains*) Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Klebsiella...pneumoniae, Staphylococcus aureus, or Moraxella catarrhalis; Acute Bacterial Sinusitis (ABS...pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis; and Uncomplicated Skin and Skin...
Source: HighBeam Research, Intranasal dLOS-CRM vaccine against Moraxella catarrhalis studied.