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Antigastrin immunogen induces immune response in phase II study.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Patients participating in a phase II clinical trial of the antigastrin immunogen G17DT as treatment for advanced pancreatic cancer were able to mount what researchers said was an "adequate antibody response."
"The prognosis for advanced pancreatic cancer remains poor," noted B.T. Brett and colleagues, Royal Free Hospital, London, England.
"Gastrin acts as a growth factor for pancreatic cancer. We describe the first study of the antigastrin immunogen G17DT in pancreatic cancer. Our aims were to determine the antibody response, safety, tolerability, and preliminary evidence of efficacy of G17DT in advanced pancreatic cancer."
Brett and team vaccinated 30 patients "with three doses of either 100 microg or 250 microg of G17DT."
They reported that "in the whole group, 20 (67%) of 30 patients produced an antibody response. The 250-microg dose resulted in a significantly greater response rate of 82% compared with 46% for the 100-microg group (p=.018)."
Treatment was well-tolerated overall. "The most significant side effects, seen in three patients, were local abscess and/or fever," the gastroenterologists said.
"The median survival for the whole group from the date of the first immunization was 187 days; median survival was 217 days for the ...
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