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Adenovirus-mediated transfer of viral IL-10 gene has potential to treat uveitis.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Gene therapy to promote systemic and local expression of viral interleukin 10 could have potential against uveitis, researchers say.
"Pathological ocular manifestations result from a dysregulation in the balance between proinflammatory type 1 cytokines and regulatory type 2 cytokines. Interleukin-10 (IL-10) is an anti-inflammatory cytokine with potent immunosuppressive effects.
"We have examined the efficiency of viral IL-10 adenovirus (Ad-vIL-10)-mediated gene transfer on experimental autoimmune uveoretinitis (EAU) induced in mice and rats by purified retinal autoantigens, respectively, interphotoreceptor binding protein (IRBP) and S-antigen (S-Ag)," said Y. Dekozak and colleagues, INSERM, Paris, France.
"B10-A mice that received a single unilateral injection of Ad-vIL-10 in the retro-orbital sinus venosus performed one day before immunization with IRBP in the footpads showed high levels of circulating vIL-10 in their sera and a significant reduction in pathological ocular manifestations," reported Dekozak and associates.
"Lower levels of IFN [interferon]-gamma and IL-2 were found in cellular supernatants from IRBP-stimulated splenic cells in these treated mice. The local effect on ocular disease of vIL-10 was neutralized completely by injection of a monoclonal anti-vIL-10 antibody, demonstrating the specificity of the treatment.
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- Adenovirus-mediated transfer of viral IL-10 gene has potential to treat uveitis.
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