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Antibiotic-resistant Streptococcus pneumoniae emerges in Vietnam.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Surveillance for Streptococcus pneumoniae resistant to penicillin and other antimicrobial agents is necessary to define the optimal empirical antibiotic therapy for meningitis in resource-poor countries such as Vietnam," state researchers in England.
C.M. Parry and colleagues studied "[t]he clinical and microbiological features of 100 patients admitted to the Centre for Tropical Diseases in Ho Chi Minh City, Vietnam, between 1993 and 2002 with invasive pneumococcal disease..."
They reported that "[a] penicillin-nonsusceptible Pneumococcus (MIC greater than or equal to 0.1 microgram/ml) was isolated from the blood or cerebrospinal fluid of 8% of patients (2 of 24) between 1993 and 1995 but 56% (20 of 36) during 1999 to 2002 (p
The researchers found just one ceftriaxone-resistant isolate (MIC 2.0 microgram/ml).
"Penicillin-nonsusceptible pneumococci were isolated from 78% of children younger than 15 years (28 of 36) compared with 25% of adults (16 of 64) (p=0.0001)," reported Parry and team. Isolation of a penicillin-nonsusceptible Pneumococcus in adults with meningitis was independently associated with referral from another hospital (p=0.005) and previous antibiotic therapy (p=0.025).
"Multilocus sequence typing showed that 86% of the invasive penicillin-resistant Pneumococcus isolates tested (12 of 14) were of the Spain(23F-1) clone," the researchers said. "The serotypes of >95% of the ...
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Source: HighBeam Research, Antibiotic-resistant Streptococcus pneumoniae emerges in Vietnam.