AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Mamu-A*01 allele has protective effect in animals.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have identified a genetic factor that protects primates against AIDS.
Zhi-Qiang Zhang and colleagues working at Merck Research Laboratories in West Point, Pennsylvania, " investigated the expression of the MHC class I allele Mamu-A*01 in simian-human immunodeficiency virus (SHIV) infection, one of the major models for evaluation of AIDS vaccine candidates."
This allele was associated with delayed disease progression and a lower degree of lymphoid tissue damage, Zhang and coauthors found.
The researchers examined the impact of Mamu-A*01 expression in rhesus monkeys. Study animals were infected with the extremely virulent 89.6P strain of SHIV, they noted.
Rhesus monkeys positive for Mamu-A*01 demonstrated significantly slower disease progression than animals without this allele. Delayed progression was partly due to potent and Mamu-A*01-restricted cytotoxic T-lymphocyte (CTL) activity, according to the report.
In addition, Mamu-A*01 expression prevented the "massive" lymph node damage seen in infected animals lacking this allele ...
- Seventeen SIV-derived CD8+ T cell Mamu-A*02-restricted epitopes identified.
- Newspaper article from: AIDS Weekly December 13, 2004 700+ words
...epitopes restricted by the high frequency molecule, Mamu-A*02. According to a study from the United States...identification has only been undertaken for two alleles, Mamu-A*01 and Mamu-B*17. As a result, these two molecules account...
- New disease progression therapy research from Duke University, Department of...
- Newspaper article from: Cancer Weekly November 17, 2009 700+ words
...Validation of a nomogram to predict disease progression following salvage radiotherapy after...Stephenson nomogram') to predict disease progression after salvage radiotherapy (SRT...of whom 30 (29%) developed disease progression after SRT during a median follow...
- Researchers Report That Oral Phenoxodiol Slows Disease Progression in...
- Press release article from: PR Newswire November 22, 2004 700+ words
...of phenoxodiol on PSA levels and disease progression. The main purpose of the study...continued for 6 months or until disease progression. Patients who were considered to...continued on 200 mg phenoxodiol until disease progression. About the results Phenoxodiol...
- Sequencing the lifetime onset of alcohol-related symptoms in older adults: is...
- Magazine article from: Journal of Studies on Alcohol Lemke, Sonne Schutte, Kathleen K. Brennan, Penny L. Moos, Rudolf H. November 1, 2005 700+ words
...can be characterized in terms of a disease-progression model, which specifies that symptoms...has progressed. If confirmed, a disease-progression model has the potential to improve...issue in assessing evidence for a disease-progression model is whether an accurate general...
- Depression may accelerate HIV disease progression.
- Newspaper article from: AIDS Alert September 1, 1992 700+ words
...people, and therefore, may hasten disease progression and death. In a study presented...differences in known predictors of disease progression - such as age, race, baseline...counts and may have greater early disease progression and mortality," Burack said...
- Disease Progression in HIV-Positive Women With Moderate to Severe...
- Behavioral Medicine Vedhara, Kav Schifitto, Giovanni McDermott, Michael March 22, 1999 700+ words
...into the role of depression in HIV disease progression. All participants had CD4+ cell...be a significant determinant of disease progression in women with advanced disease and...immune indices as markers of HIV disease progression. These have included HIV-related...
- REVLIMID(R) (lenalidomide) Significantly Delays Time to Disease Progression in...
- Press release article from: PR Newswire Europe June 7, 2005 700+ words
...Primary Endpoint of Time-To-Disease Progression (TTP) Demonstrated in Two Pivotal...010) - The median time-to-disease progression with REVLIMID plus dexamethasone...compared with median time-to-disease progression of 20.6 weeks for placebo plus...
- RAPID DISEASE PROGRESSION FOLLOWING ACUTE INFECTION BY POLYTROPIC HIV-1.(Brief...
- Magazine article from: Journal of the Alabama Academy of Science January 1, 2000 700+ words
RAPID DISEASE PROGRESSION FOLLOWING ACUTE INFECTION BY...is a cause or an effect of disease progression is not known. Patient WEAU...rapid CD4+ cell decline and disease progression to AIDS and death. A unique...
