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Intranasal immunization with sperm-specific antigen has vaccine potential.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that an intranasal vaccine they developed elicited immunoglobulin A (IgA) and IgG antibodies in the sera and vaginal secretions of mice.
"The common mucosal immune system (CMIS) has developed as a barrier for the numerous encounters between the host and various pathogens. It is possible to exploit this system to induce secretion of IgA antibody which inhibits sperm penetration in the female genital tract," stated A. Hasegawa and colleagues, Hyogo Medical University.
They investigated "the immunogenicity of a human sperm surface antigen (CD52) introduced by intranasal immunization ... with a view to developing a contraceptive vaccine."
"A synthetic peptide corresponding to CD52 core peptide (GQNDTSQTSSPS) was prepared and conjugated with diphtheria toxoid (DT) as a carrier protein. The immunogen was given to mice with DOTAP: cholesterol liposome adjuvant intranasally, followed by determination of Ig and IgA class antibody levels in the sera and vaginal washes."
The researchers reported that "CD52 core peptide elicited IgA class as well as Ig antibodies both in the sera and vaginal secretions after intranasal immunization. An additional nasal inoculation after decrease of ...
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