AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Intratumoral injection of dendritic and irradiated glioma cells studied.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Malignant astrocytoma is the most common primary brain tumor in adults. The median survival of patients with malignant astrocytomas (high-grade astrocytomas) is about 1-2 years, despite aggressive treatment that includes surgical resection, radiotherapy, and cytotoxic chemotherapy. Therefore, novel therapeutic approaches are needed to prolong survival," say researchers in Japan.
T. Kikuchi and colleagues, Jikei University, "investigated antitumor immunity conferred by the intratumoral injection of dendritic (DC) and irradiated glioma cells (IR-GC) in a mouse brain tumor model."
They reported that "[i]ntratumorally-injected DC migrated to the lymph nodes and elicited systemic immunity against autologous glioma cells. In a treatment model, intratumoral injection of DC and IR-GC prolonged the survival of brain tumor-bearing mice."
The researchers noted a reduction in efficacy "when studies were performed in mice depleted of CD8+ T cells."
"Administration of DC or IR-GC alone had no effect on survival of brain tumor-bearing mice. CTL ...
- Radiation, intratumoral injection turn on immune system to attack tumor...
- Newspaper article from: Cancer Weekly March 18, 2003 700+ words
...role because several mechanisms allow glioma cells to grow and spread without being detected...enlisting other "cytokines" against glioma cells. Furthermore, dendritic cells are...to be extremely effective in killing glioma cells. This is the first study in which dendritic...
- Radiation, intratumoral injection turn on immune system to attack tumor cells.
- Newspaper article from: Immunotherapy Weekly March 19, 2003 700+ words
...role because several mechanisms allow glioma cells to grow and spread without being detected...enlisting other "cytokines" against glioma cells. Furthermore, dendritic cells are...to be extremely effective in killing glioma cells. This is the first study in which dendritic...
- The functional significance of VEGF receptors on glioma cells is minimal.
- Newspaper article from: Angiogenesis Weekly June 4, 2004 700+ words
...functional significance of VEGF receptors on glioma cells is minimal. According to a study from...of VEGF have been suspected. "Since glioma cells are known to produce large amounts of...expression and effects of VEGF on glioma cells. The three glioma cell lines and eight...
- TALL-104 cells injure glioma cells by apoptotic and necrotic pathways.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...net) -- TALL-104 cells injure glioma cells by apoptotic and necrotic pathways...evidence that TALL-104 cells injured glioma cells by both apoptotic and necrotic pathways...percentages of both apoptotic and necrotic glioma cells increased after TALL-104 cell/glioma...
- TRAIL triggers apoptosis in human malignant glioma cells.
- Newspaper article from: Medical Devices & Surgical Technology Week January 18, 2004 700+ words
...malignant gliomas. "Many malignant glioma cells express death receptors for tumor necrosis...that could overcome TRAIL resistance in glioma cells. TRAIL induced apoptosis through death...triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways...
- Endocannabinoid system protects glioma cells against Tat-induced cytotoxicity.
- Newspaper article from: Pain & Central Nervous System Week March 3, 2003 700+ words
...Esposito and colleagues published their study in the Journal of Biological Chemistry (The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity - Mechanism and regulation. J Biol Chem, 2002;277(52):50348...
- Bromelain reversibly inhibits invasive properties of glioma cells.(Abstract)
- Magazine article from: Alternative Medicine Review Tysnes, BB Maurer, HR Porwol, T April 1, 2002 700+ words
...antiinflammatory, antimetastatic, antithrombotic, and fibrinolytic activities. In this study, we tested bromelain's effects on glioma cells to assess whether bromelain could be a potential contributor to new antiinvasive strategies for gliomas. Several complementary...
- IL-2-activated NK cells enhance effect of tumor vaccine in brain cancer.
- Newspaper article from: Cancer Vaccine Week March 29, 2004 700+ words
...NewsRx.net) -- Intratumoral injection of IL-2-activated...cell vaccine and intratumoral injection of INK cells induced...glioma. Rat 9L glioma cells were inoculated...alone. However, intratumoral injection of rat INK cells...
Source: HighBeam Research, Intratumoral injection of dendritic and irradiated glioma cells...