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Nasal administration of CTB-insulin induces active tolerance in murine model.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Nasal administration of beta cell-derived auto-antigens has been reported to suppress the development of autoimmune diabetes. We investigated the tolerogenic effects of insulin conjugated to the B subunit of cholera toxin (CTB)," reported researchers in France.
C. Aspord and colleagues found that "[n]asal administration of 1 microgram of CTB-insulin significantly delayed the incidence of diabetes in comparison to CTB treated mice. However, administration of 4 or 8 microgram of the conjugate had no protective effect."
They also reported that "[p]rotection induced by CTB-insulin was transferred to naive recipients by splenic CD4+ T cells. This result favors an active cellular mechanism of regulation, which was lost using higher (4-8 microgram) or lower (0.1-0.5 microgram) amounts of the conjugate.
"When coadministered with diabetogenic T cells, splenic T cells from CTB-insulin-treated mice reduced the lymphocytic infiltration of the islets," the researchers continued.
"Reverse transcription-polymerase chain reaction analysis of recipients' pancreatic glands revealed an increase of TGF-beta and IL-10 transcripts after donor mice tolerization, while levels of IFN-gamma and IL-4 RNAs were unchanged," reported Aspord's group.
Among their other findings:
* "...a significant increase of T-cell proliferation after unspecific stimulation in the spleen and pancreatic lymph ...
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Source: HighBeam Research, Nasal administration of CTB-insulin induces active tolerance in...