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Heat shock protein complex successfully treats subset of malignant melanoma patients.
2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A small but significant percentage of patients with malignant melanoma experienced complete remission or stabilization of the disease after vaccination with autologous tumor-derived heat shock protein gp96-peptide complexes.
Filiberto Belli and colleagues working in Italy and the U.S. vaccinated 42 patients who had stage IV malignant melanoma with at least one cycle (four weekly injections) of a vaccine containing autologous, tumor-derived heat shock protein gp96-peptide complexes (HSPPC-96). Twenty-one of the patients in whom no progression occurred received a second cycle consisting of four biweekly injections.
A complete response (CR) lasting either 559+ or 703+ days was experienced by 2 of 28 patients with measurable disease. Another three patients had stable disease (SD) lasting 153, 191, or 272 days. Three patients experienced long-term disease-free survival (Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings. Journal of Clinical Oncology, 2002;20(20):4169-4180).
A significant increase in the number of tumor-specific T cells was found in 11 of 23 patients after vaccination. A high frequency of increased T-cell activity was noted in patients who experienced a significant clinical response.
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Source: HighBeam Research, Heat shock protein complex successfully treats subset of malignant...