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Clinical trials evaluating once-yearly zoledronic acid in osteoporosis to begin.
2002 DEC 19 - (NewsRx.com & NewsRx.net) -- Investigators across the United States are currently recruiting participants for studies evaluating the safety and effectiveness of a once-yearly infusion of the Novartis drug zoledronic acid for the treatment of osteoporosis.
These studies are part of an overall clinical program known as HORIZON (health outcomes and reduced incidence with zoledronic acid once yearly).
The HORIZON program is the first to study a once-yearly dosing regimen for treating osteoporosis. HORIZON is the first program to, in a single study, prospectively evaluate both spine and hip fracture benefits as primary endpoints in women with postmenopausal osteoporosis.
The program will also evaluate a single dose of zoledronic acid given once for the treatment of Paget disease, a rare but debilitating bone disease. Worldwide, approximately 11,000 patients in 400 trial centers on four continents will be enrolled in the HORIZON program, which is one of the most comprehensive drug evaluation programs ever undertaken in the area of metabolic bone diseases.
The HORIZON pivotal fracture trial is a multinational, multicenter, double-blind, randomized, placebo-controlled, phase III study to evaluate the safety and efficacy of zoledronic acid in the treatment of osteoporosis in postmenopausal women taking calcium ...
- Zoledronic acid after hip fracture.(MINDFUL PRACTICE)
- Magazine article from: Internal Medicine News Ebbert, Jon O. Tangalos, Eric G. February 15, 2008 700+ words
...mortality in the zoledronic acid group. Of great...intuitively, hip fracture would have the...Lyles, et al. Zoledronic acid and clinical fractures...mortality after hip fracture. N. Engl. J...ambulatory before the hip fracture, and had two...intravenous ...
- MediaWatch: `Annual jab cuts fractures'.(zoledronic acid injection reduce hip...
- Newspaper article from: Pulse May 10, 2007 700+ words
...to the Daily Mail and Times. The source An 8,000-woman study published in the New England Journal of Medicine found zoledronic acid reduced hip fractures by 41% when given as an annual injection. It also reduced fractures of the vertebrae by 70% compared...
- Zoledronic Acid Injection (Reclast®).
- Magazine article from: Internal Medicine Alert October 29, 2007 700+ words
...month interval.5 Comments Zoledronic acid is a long-acting bisphosphonate...7736). Annual doses of zoledronic acid significantly reduced morphometric...op after a low trauma hip fracture (n = 2127), zoledronic acid significantly reduced any...
- Yearly zoledronic acid infusion cuts fractures.(Metabolic Disorders)
- Magazine article from: Family Practice News Moon, Mary Ann October 15, 2007 700+ words
...annual infusion of zoledronic acid reduced the rate...surgical repair of a hip fracture, according to Dr...Reduced Incidence with Zoledronic Acid Once Yearly (HORIZON...Surgical Repair of Hip Fracture B Zoledronic acid Placebo (n = 1...
- Clinical Matters: Zoledronic cuts risk.(usage of intravenous zoledronic acid on...
- Magazine article from: Chemist & Druggist November 10, 2007 700+ words
Annual treatment with intravenous zoledronic acid following hip fracture reduces the risk of further fractures and improves survival, according to a study published in the New England Journal of Medicine. NEJM 2007; 357: 1799-809 Copyright: CMP Information Ltd.
- Zoledronic acid slows bone loss in osteopenia.(ENDOCRINOLOGY)(Report)
- Magazine article from: Internal Medicine News Sullivan, Michele G. May 15, 2009 700+ words
...yearly infusion of zoledronic acid appears to prevent...already had a hip fracture, two randomized...has shown that zoledronic acid also benefits...who have had a hip fracture--particularly...with a recent hip fracture who were randomized...infusion of 5 ...
- Novartis Launches First Series of Clinical Trials Evaluating Once-Yearly...
- Press release article from: PR Newswire November 14, 2002 700+ words
...both spine and hip fracture benefits as primary...single dose of zoledronic acid given once for...administration of zoledronic acid in preventing...after a recent hip fracture. This study is...of a low trauma hip fracture but were ambulatory...yearly 5 mg ...
- Novartis launches first series of clinical trials evaluating once-yearly...
- News wire article from: Asia Africa Intelligence Wire November 14, 2002 700+ words
...Incidence with Zoledronic Acid ONce Yearly...both spine and hip fracture benefits as...single dose of zoledronic acid given once for...administration of zoledronic acid in preventing...after a recent hip fracture. This study...
- Clinical trials evaluating once-yearly zoledronic acid in osteoporosis to begin.
- Newspaper article from: Drug Week December 20, 2002 700+ words
...both spine and hip fracture benefits as primary...single dose of zoledronic acid given once for...administration of zoledronic acid in preventing...after a recent hip fracture. This study is...of a low trauma hip fracture but were ambulatory...50-mg dose ...
- Single Dose of Zoledronic Acid Yields Significantly Higher, Faster Response...
- Press release article from: PR Newswire May 18, 2004 700+ words
...First filing for zoledronic acid in metabolic bone...seen so far with zoledronic acid," said Joerg Reinhardt...fractures following a hip fracture in men and women...approvals to market zoledronic acid for treatment of...
Source: HighBeam Research, Clinical trials evaluating once-yearly zoledronic acid in...