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Angiogenic, neurotrophic factors are expressed in human amnion, choriodecidua.
2002 DEC 19 - (NewsRx.com & NewsRx.net) -- A recent study, conducted by researchers in New Zealand, aimed "to identify the novel or differential expression of growth- or development-associated genes in the human gestational membranes that might play roles in pregnancy or in term or preterm parturition."
"Complementary DNA arrays were probed with [alpha(33)P]dCTP-labeled-complementary DNA that was prepared from the RNA of reflected amnion and choriodecidua that represent term not-in-labor, term spontaneous labor, and preterm labor with and without chorioamnionitis (n=4 per group). Differential expression (term not-in-labor vs. term spontaneous labor or preterm labor with chorioamnionitis vs. preterm labor without chorioamnionitis) was evaluated by Wilcoxon tests," stated K.W. Marvin and colleagues, University of Auckland.
The researchers reported that "all 16 amnion samples expressed angiogenic factors (endothelin-2 and -3, vascular endothelial growth factor, and vascular endothelial growth factor-B) and neurotrophic factors (ephrin-A2, ephrin receptors-A2, -B1, -B3, -B4, and -B5, neuropilin-2, p75/nerve growth factor receptor and semaphorin-F).
"In both amnion and choriodecidua, the expression of vascular endothelial growth factor and the angiopoietin receptor, Tie-2, were greater with term spontaneous labor than with term not-in-labor (p
They reported, "Ephrin-A1 expression increased with term spontaneous labor in both tissues (p
Marvin ...
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Source: HighBeam Research, Angiogenic, neurotrophic factors are expressed in human amnion,...