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2002 DEC 19 - (NewsRx.com & NewsRx.net) -- Hormone replacement therapy has been the subject of some controversy recently concerning potential benefits and risks.
A study from the University of California, San Francisco, the San Francisco VA Medical Center, Wyeth-Ayerst Research, and the University of California, San Diego, examines whether this therapy can improve cognitive function in elderly women with coronary disease.
Previous findings of several randomized trials suggest that estrogen therapy improves cognition in postmenopausal women without pre-existing dementia. According to the authors, " all of these trials were small (18-64 participants), several reported improved cognition in the estrogen-treated group but did not compare these changes with those in the placebo group, and most enrolled women were recently menopausal and likely to be suffering from menopausal symptoms. Relief of vasomotor symptoms and insomnia by estrogen therapy might have resulted in better concentration and improvement in cognitive performance."
Using subjects from the Heart and Estrogen/Progestin Replacement Study (HERS), a randomized, placebo-controlled trial involving 2763 women with coronary disease, participants at 10 of the 20 HERS centers were invited to enroll in the cognitive function substudy. Subjects were followed for more than 4 years and cognitive function was measured in 517 women in the hormone group and 546 in the ...