AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Study: Remune antigen with CpG ODN may offer HIV protection.
2002 DEC 18 - (NewsRx.com & NewsRx.net) -- The Immune Response Corp. (IMNRD) announced the final results of a study at McMaster University Health Sciences Centre suggesting that use of Remune antigen in combination with oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses in genital and vaginal tracts and protected animals from infection after virus challenge.
The study was designed to ascertain if this approach might be an effective means of inducing protection and potent immune responses in the genital tract against infection with HIV-1.
"Our results suggest that Remune antigen plus CpG ODN when given as a intranasal immunization can induce significant levels of HIV-specific immunity in the genital tract of mice," said Dr. Kenneth L. Rosenthal, lead investigator of the study at McMaster University Health Sciences Centre in Hamilton, Canada. "Furthermore, these animals were protected from virus challenge in the genital tract. These results suggest that a similar approach should be tested to determine if humans can be protected from sexually transmitted HIV-1 infection through a intranasal immunization."
The study, published in The Journal of Infectious Diseases (2002;186:1098-1105), evaluated vaginal and systemic immune responses and protection from vaginal challenge elicited after intranasal immunization of mice with Remune antigen in combination with CpG ODN. Mice immunized with Remune antigen plus CpG ODN had enhanced levels of anti-p24 IgG and IgA antibodies in serum and vaginal washes, and increased production of chemokines and Interferon gamma.
Further ...
- Study: Remune antigen with CpG ODN may offer HIV protection.(Brief Article)
- Newspaper article from: AIDS Weekly December 16, 2002 700+ words
...Our results suggest that Remune antigen plus CpG ODN when given as a intranasal...Mice immunized with Remune antigen plus CpG ODN had enhanced levels of...intranasal immunization with Remune antigen plus CpG ODN protected mice against...
- A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG...
- Magazine article from: Journal of Clinical Investigation Shen, Hong Iwasaki, Akiko August 1, 2006 700+ words
...plasmacytoid DCs (pDCs) are required for CpG ODN-mediated protection against lethal vaginal...and stromal compartments must respond to CpG ODN via TLR9 and to type I IFNs through IFN...and spatially controlled targeting of CpG ODN to pDCs and epithelial cells can potentially...
- DC and CpG ODN immunotherapy cures large murine tumors that resist...
- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...pulsed DC or peritumoral injections of CpG ODN, both effective for the treatment of...was strongly increased by coinjection of CpG ODN, resulting in a transient control of...injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with peritumoral...
- DC and CpG ODN immunotherapy cures large murine tumors that resist chemotherapy.
- Newspaper article from: Cancer Weekly January 21, 2003 700+ words
...pulsed DC or peritumoral injections of CpG ODN, both effective for the treatment of...was strongly increased by coinjection of CpG ODN, resulting in a transient control of...injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with peritumoral...
- Trypanosoma cruzi antigen and CpG-ODN protect against trypomastigotes.
- Newspaper article from: Health & Medicine Week April 26, 2004 700+ words
...oligodeoxynucleotides containing CpG-motifs (CpG-ODN) are capable of driving immunity toward...the ability of Ag163B6/cruzipain plus CpG-ODN to induce immunoprotection against a lethal...Mice were immunized with Ag163B6 + CpG-ODN showing high specific antibody titers...
- The Immune Response Corporation Announces Study Suggesting Protection From HIV...
- Press release article from: PR Newswire October 17, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses...suggest that REMUNE(R) antigen plus CpG ODN when given as a intranasal immunization...REMUNE(R) antigen in combination with CpG ODN. Mice immunized with REMUNE(R) antigen...
- CpG ODN properties might be useful in developing immunotherapy adjuvants.
- Newspaper article from: Immunotherapy Weekly January 22, 2003 700+ words
...homeostatic mechanism for the Th1-Th2 balance," the researchers said. "Overproduction of IFN-gamma was downregulated by CpG ODN-induced IL-10 via modulation of IL-12 production." They concluded that their "data suggest that CpG ODNs may inhibit...
- New life sciences data have been reported by researchers at Anhui Medical...
- Newspaper article from: Biotech Week June 3, 2009 700+ words
A report, 'CpG-ODN enhances ingestion of apoptotic neutrophils by...synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODN) in vitro." "The results showed that, while CpG-ODN at the experimental concentration had no cytotoxic...
Source: HighBeam Research, Study: Remune antigen with CpG ODN may offer HIV protection.