AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Carcinoembryonic antigen expressed by head and neck cancer tumors.
2002 DEC 18 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Many head and neck tumors were found to express human carcinoembryonic antigen (CEA), providing a potential target for vaccine therapy of head and neck cancers (HNC).
Overexpression of CEA by gastrointestinal carcinomas has been widely studied. However, investigations into its expression by head and neck tumors are lacking. Erik S. Kass and colleagues at the U.S. National Institutes of Health evaluated the expression of CEA by squamous cell carcinomas of the head and neck and the potential for vaccine therapy directed against CEA for treatment of head and neck cancers.
The investigators performed immunohistochemical analyses of 69 squamous cell carcinoma tumors using a monoclonal antibody (COL-1) specific for CEA and found that most of the tumor samples were CEA-positive, although cell surface expression was low.
Reverse transcription PCR revealed CEA expression in 7 out of 10 human HNC cell lines. Detection of the CEA protein was possible in the lysates from all 7 of the cell lines that expressed the antigen. SDS-PAGE combined with Western blot analysis of the 7 CEA-positive cell lines demonstrated the presence of an agent that possessed the same molecular weight as CEA and reacted with COL-1. Cytoplasmic staining intensity of the cells was moderate to strong in the 7 CEA-positive cell ...
- CEA-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer.
- Newspaper article from: Medical Devices & Surgical Technology Week December 21, 2003 700+ words
...OV798 preferentially replicates in and kills CEA-producing colorectal cancer cell lines such as LoVo and SW1463, but its replication is attenuated by 1000-fold in the CEA-negative cell lines Colo-320DM (colon cancer), PA-1...
- L-3-phosphoserine phosphatase and CEA detect gastric cancer micrometastasis.
- Newspaper article from: Genomics & Genetics Weekly July 23, 2004 700+ words
...phosphoserine phosphatase and CEA detect gastric cancer micrometastasis...expression of gastric cancer cell lines established from peritoneal...of carcinoembryonic antigen (CEA) mRNA by means of real-time...The quantity of L3-PP and CEA correlated with wall penetration...
- CEA Immunization Induces Protective Host Immunity.
- Newspaper article from: Immunotherapy Weekly Marble, Michelle March 15, 1999 700+ words
...virus hosting the carcinoembryonic antigen (CEA) induces a protective antitumor immune response. CEA is an oncofetal antigen that is expressed in...have been exploring the possibility of using CEA in tumor immunization protocols. Erik Kass...
- CEA and NARDA Announce Strategic Partnership.
- Press release article from: Business Wire February 22, 2005 700+ words
...The Consumer Electronics Association (CEA) and the North American Retail Dealers...partnership. Under the partnership agreement, CEA and NARDA will create programs and training...furniture, and other consumer home products. CEA represents nearly 2,000 corporate members...
- CEA Drives Increased Efforts to Educate Consumers on Transition to Digital...
- Press release article from: Business Wire March 15, 2006 700+ words
...WASHINGTON -- The Consumer Electronics Association (CEA(R)) today announced a broad-based, member...switch over to all digital broadcasting," said CEA President and CEO Gary Shapiro. "CEA has long supported a cut-off date but our job...
- CEA Standards Working Group Meeting to Develop Technical Specifications for...
- Press release article from: Business Wire June 22, 2005 700+ words
...The Consumer Electronics Association's (CEA) Mobile Electronics Committee's MOST...meeting will be held on July 25, during CEA's 2005 Summer Technology & Standards Forum in Denver, CO. CEA works in conjunction with the MOST Cooperation...
- CEA and CNET Release New Consumer Sentiment Indexes.
- Press release article from: Business Wire August 12, 2008 700+ words
...Electronics ARLINGTON, Va. -- The Consumer Electronics Association (CEA)[R] and CNET (www.CNET.com) today announced the launch of the CEA-CNET Consumer Sentiment Indexes. The CEA-CNET Indexes provide a look at consumer confidence for the...
- CEA Promotes Karen Chupka and Todd Thibodeaux to Senior Vice President...
- Press release article from: Business Wire April 18, 2006 700+ words
...The Consumer Electronics Association (CEA(R)) today announced the launch of its...president titles for the same departments. CEA's new International Department will coordinate...international trade strategies and oversee CEA's operations in China, which includes...