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Cocaine-exposed infants are predisposed to necrotizing enterocolitis.
2002 DEC 12 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Cocaine has become a popular illicit drug in our society, and pregnant women are not immune from this epidemic. Recently, there have been several references in the literature describing an association between prenatal cocaine exposure and the subsequent development of necrotizing enterocolitis in the neonate, but the mechanism underlying this relationship remains speculative."
L.P. Ward and colleagues, Cincinnati Children's Hospital Medical Center, Ohio, said that "[b]ecause alpha-2 adrenergic receptors are thought to play a role in the autoregulatory mechanism in the newborn intestine that responds to hypoxia and ischemia, we examined the expression of this receptor in the intestine of embryonic rats exposed to low- and high-dose cocaine in utero."
According to their study protocol, "pregnant Sprague Dawley rats were injected daily with either saline, low-dose cocaine, or high-dose cocaine beginning on embryonic day 5 (E 5) and continuing to E 20. Mothers were killed on E 16, E 17, E 18, E 19, and E 20. Embryos were frozen and stored at -80 degrees C. In situ hybridization was performed on 20-micrometer sections with S-35-labeled oligonucleotide probes specific for the alpha-2A adrenergic receptor subtype."
"Densitometric analysis revealed a significant decrease in the alpha-2A receptor expression in ...
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Source: HighBeam Research, Cocaine-exposed infants are predisposed to necrotizing enterocolitis.