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Fetal RHD genotype determined via maternal serum during the first trimester.
2002 DEC 12 - (NewsRx.com & NewsRx.net) -- Researchers in France have devised a reliable, noninvasive technique to analyze fetal RHD genotype in maternal serum during the first trimester of pregnancy.
"Fetal RHD genotype determination is useful in the management of sensitized RhD-negative pregnant women. It can be ascertained early during pregnancy by chorionic villus sampling (CVS) or amniocentesis. However, these procedures are invasive, resulting both in an increased risk of fetal loss and in an increased severity of immunization due to fetomaternal hemorrhage," wrote J.M. Costa and colleagues at the American Hospital, Paris.
Serum samples from 106 RHD-negative women were collected during the first trimester of their pregnancy. A real-time polymerase chain reaction assay was used to detect the RHD gene in the samples "and the results compared with those obtained later in pregnancy on amniotic fluid cells and by RHD serology of the new-born," the researchers said.
They reported that "[a]ll sera from women carrying a RhD positive fetus (n=62) gave positive results for RHD gene detection and sera from women carrying a ...
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Source: HighBeam Research, Fetal RHD genotype determined via maternal serum during the first...