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Obesity increases risk of death from ovarian cancer in postmenopausal women.
2002 DEC 12 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Data from a large prospective study revealed obesity is a significant risk factor for death from ovarian cancer among postmenopausal women, according to investigators in the U.S.
"Endogenous hormones may play a role in ovarian carcinogenesis," said Carmen Rodriguez and colleagues at the American Cancer Society. "Postmenopausal obesity, although associated with higher circulating levels of estrogen and androgens, has not been linked consistently to ovarian cancer."
The investigators followed 300,537 women who did not have a history of cancer, hysterectomy, or ovarian surgery at initiation of the study for 16 years. The relations between mortality from ovarian cancer and height and body mass index (BMI) were analyzed (Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women. Cancer Epidemiology Biomarkers and Prevention, 2002;11(9):822-828).
Over the course of the study, 1511 participants died from ovarian cancer. Overweight women (BMIgreater than or equal to25 kg/m[superscript]2) were 1.2 times more likely and obese women (BMIgreater than or equal to30) were 1.3 times more likely to die from ovarian cancer than were lean women. However, hormone replacement therapy appeared to offer some protection against ovarian cancer mortality risk, because obese women who had ever used postmenopausal ...
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Source: HighBeam Research, Obesity increases risk of death from ovarian cancer in postmenopausal...