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Antigenic relationships compared among six viral genotypes.
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- Virologists in Sweden reported the results of an antigenic comparison of mumps virus genotypes A, C, D, G, H, and I.
These six had been "genotyped on the basis of the small hydrophobic protein gene sequence," according to the study report.
"Monoclonal antibodies directed against the hemagglutinin-neuraminidase protein of the SBL-1 strain of genotype A were used in immunofluorescence tests with different mumps virus strains. In addition, the six virus genotypes were compared by cross-neutralization tests with human postvaccination sera after vaccination with the Jeryl Lynn (JL) strain of mumps virus and with rabbit hyperimmune sera directed against the A or D genotypes of mumps virus," wrote C. Orvell and colleagues, Karolinska Institute, Stockholm.
"Genotypes C, D, G, H, and I could not be antigenically separated," they reported. "In contrast, three different virus strains of genotype A - SBL-1, JL, and Kilham - were distinct and were found to represent three different serotypes within the A genotype of mumps virus."
Orvell ...
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Source: HighBeam Research, Antigenic relationships compared among six viral genotypes.