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T-cell clones shrink tumors.
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- A preliminary clinical trial suggests that armies of T cells generated in the lab can be injected into patients to halt the spread of cancerous tumors.
The study, conducted by Dr. Cassian Yee, a researcher at the Fred Hutchinson Cancer Research Center, involved 10 people diagnosed with advanced melanoma. For each patient immune system cells able to identify and target melanoma were extracted and cloned. The cloned cells were expanded in the lab and reinjected into the patient. The results of the study showed that in five patients tumors stopped growing for up to one year and in three of the patients the tumors appeared to shrink.
"While we did not expect to cure the cancers, the technique appears to benefit patients by curbing the spread of their tumors," said Yee.
One strategy for treating cancer is to sensitize the immune system to the presence of tumors so it can attack the cancerous cells. Vaccinating patients with proteins present on the cancerous cells could kick the immune system into action. Instead of relying on the immune system to manufacture a defense, however, Cassian Yee and colleagues tried supplying ready-made soldiers. In the lab, ...
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Source: HighBeam Research, T-cell clones shrink tumors.