AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Distinct mechanisms of intestinal priming lead to cross-protection.
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- A study of the mechanisms of immunological cross-protection has shown that intestinal priming promotes protection of the upper and lower respiratory tracts through distinct mechanisms.
"A main feature of the common mucosal immune system is that lymphocytes primed in one mucosal inductive site may home to distant mucosal effector sites. However, the mechanisms responsible for such cross-protection remain elusive," wrote A.W. Zuercher and colleagues, University of Pennsylvania.
To discern how cross-protection occurs, the researchers used SCID mice with mucosal infection with reovirus.
"In immunocompetent mice local duodenal priming protected against subsequent respiratory challenge," Zuercher's team reported.
"In the upper respiratory tract this protection appeared to be mainly mediated by specific IgA [immunoglobulin A]- and IgG2a-producing B cells, whereas ex vivo active effector memory CTL [cytotoxic T-lymphocytes] were found in the lower respiratory tract.
"In accordance with these findings, clearance of reovirus from the lower respiratory tract, but not from the upper respiratory tract, of infected SCID mice upon transfer of gut-primed ...
- Distinct mechanisms of intestinal priming lead to cross-protection.
- Newspaper article from: Immunotherapy Weekly December 11, 2002 700+ words
...from the lower respiratory tract, but not from the upper respiratory tract, of infected...reveals that intestinal priming leads to protection...versus lower respiratory tract through intestinal priming. J Immunol...
- Respiratory tract infection Rx habits highlighted.(Infectious Diseases)
- Magazine article from: Pediatric News Boschert, Sherry November 1, 2006 700+ words
...narrow-spectrum antibiotics for respiratory tract infections in a national managed...outpatient antimicrobial prescribing for respiratory tract infections by specialty. They studied...physicians for 26,875 patients with respiratory tract infections from 2001 through 2003...
- Physician prescribing habits highlighted for RTIs.(Infectious...
- Magazine article from: Internal Medicine News Boschert, Sherry November 15, 2006 700+ words
...narrow-spectrum antibiotics for respiratory tract infections in a national managed...outpatient antimicrobial prescribing for respiratory tract infections by specialty. They studied...physicians for 26,875 patients with respiratory tract infections from 2001 through 2003...
- Antibiotic prescribing in respiratory tract infections: first do no...
- Magazine article from: CME: Your SA Journal of CPD Decloedt, E.H. Maartens, G. November 1, 2008 700+ words
...nocere or first to do no harm. Most respiratory tract infections seen in primary care are...respond to antibiotics. The few respiratory tract infections that are bacterial are...versus the risks of treating mild respiratory tract infections to illustrate how irrational...
- Upper respiratory tract infections.(RESPIRATORY CLINICAL)
- Magazine article from: FOCUS: Journal for Respiratory Care & Sleep Medicine Wheeler, David March 22, 2005 700+ words
...or enduring, the simple Upper Respiratory Tract Infection or URTI. It is not...treatment and care of the common upper respiratory tract infection. This is not surprising, as upper respiratory tract infections, along with nasal...
- Respiratory tract reinfections by the new human metapneumovirus in an...
- Magazine article from: Emerging Infectious Diseases Pelletier, Gilles Dery, Pierre Abed, Yacine Boivin, Guy September 1, 2002 700+ words
...has been recently associated with respiratory tract infections in young children. We...immunocompromised child who had severe lower respiratory tract infections during two consecutive...the adenoviruses--cause seasonal respiratory tract infections in young children. Symptoms...
- Physiology-based kinetic modeling of vapors toxic to respiratory tract works.
- Newspaper article from: Biotech Week April 16, 2003 700+ words
...kinetic modeling of vapors toxic to the respiratory tract are beneficial. "The respiratory tract is frequently identified as a site...Toxicokinetics of vapors in the respiratory tract are defined by absorption, distribution...
- Recurrent Respiratory Tract Infections and Dysphagia in a Child with an Aortic...
- Magazine article from: Southern Medical Journal Pumberger, Wolfgang Voitl, Peter Gopfrich, Hubert February 1, 2002 700+ words
ABSTRACT: Recurrent respiratory tract infections and dysphagia after...the esophagus and frequent respiratory tract infections revealed right...be the cause of recurrent respiratory tract difficulties and dysphagia...
