AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Tumor vaccine raises antigen-specific response in gastric cancer patients.
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical collaborators in Japan and Sweden have completed a phase I trial of peptide-pulsed dendritic cells in gastric cancer patients.
Scientists have identified the tumor-associated antigen HER-2/neu in some gastric cancers. Previous studies have shown dendritic cells made to overexpress the oncogene HER-2/neu act as cancer antigens in tumor vaccines. Medical researchers are currently evaluating whether or not such vaccines would be effective for treating gastric cancer.
Koji Kono and colleagues, Yamanashi Medical University, Japan, collaborated with medical investigators at Karolinska Hospital in Stockholm, Sweden, to conduct the clinical trial of nine gastric cancer patients.
According to Kono and coauthors, each of the patients had tumors that overexpressed HER-2/neu. In addition, each of the patients was positive for HLA-A2 cytotoxic specific lymphocytes (CTLs), signaling their ability to process tumor antigens.
Researchers administered four doses of the HER-2/neu-pulsed cells to each of the patients.
"There were no serious adverse effects noted in the immunized patients," said Kono and coauthors.
A survey of the patient's cells before and after immunization showed that before immunization, none had developed antigen-specific recognition of the HER-2/neu peptide. After immunization, six of the nine patients exhibited antigen-specific response (Dendritic cells pulsed with ...
- Tumor vaccine raises antigen-specific response in gastric cancer patients.
- Newspaper article from: Drug Week December 13, 2002 700+ words
...pulsed dendritic cells in gastric cancer patients...immunized gastric cancer patients...pulsed dendritic cells lead to partial...pulsed dendritic cells may offer...patients with gastric cancer This article...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Future psoriasis drugs may target role of dendritic cells.(Rx)
- Magazine article from: Internal Medicine News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...been published since 2003) suggest dendritic cells also play a role by activating the...
- Decidual CD83+ dendritic cells implicated in some recurrent miscarriages.
- Magazine article from: Women's Health Weekly April 15, 2004 700+ words
...NewsRx.net) -- Decidual CD83+ dendritic cells may contribute to some cases of recurrent...Potent immunostimulatory (CD83) dendritic cells have recently been identified in the...sought to determine "whether decidual dendritic cells could play a role in the etiology...
Source: HighBeam Research, Tumor vaccine raises antigen-specific response in gastric cancer...