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Oral tolerance with HSP 65 attenuates Mtb- and high-fat diet-induced lesions.(heat shock protein)
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- Researchers in Israel conducted a study of the "efficacy of oral tolerance with heat shock protein (HSP) 65 in two apparently nonoverlapping models of murine atherosclerosis."
Providing background information for their work, D. Harats and colleagues, Chaim Sheba Medical Center, Institute for Lipid and Atherosclerosis Research, noted several points:
* "Atherosclerosis is considered to be a chronic inflammatory process."
* "Autoimmune mechanisms have been shown to influence atherogenesis in experimental animal models."
* "Heat shock protein 65 is a candidate antigen thought to drive a proatherogenic immune-mediated response."
* "Mucosal tolerance is a therapeutic means of accomplishing immune unresponsiveness toward a given antigen by feeding it before active induction of the disorder."
In this study, "[l]ow-density lipoprotein receptor deficient mice were fed with different doses of HSP65 every other day for 10 days. Feeding with either bovine serum albumin (BSA) or phosphate buffered saline (PBS) served as control. One day after the last feeding, mice were challenged either by immunization with heat-killed Mycobacterium tuberculosis or by a high fat diet."
- Oral tolerance with HSP 65 attenuates Mtb- and high-fat diet-induced lesions.
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...agreement to develop AutoImmune's oral tolerance pharmaceuticals for the treatment of...years, the clinical development of oral tolerance products for diabetes, including Phase...as well as future generations of oral tolerance products for autoimmune-mediated...
- Model of sensitization and oral tolerance to peanut protein developed.
- Newspaper article from: Biotech Week December 29, 2004 700+ words
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- Press release article from: PR Newswire July 3, 1996 700+ words
...demonstrate the cellular mechanism of oral tolerance in humans. The laboratory studies...data that support the rationale for oral tolerance as a therapeutic approach to treating...animal models occurs in humans." Oral tolerance capitalizes on specialized immune mechanisms...
- Oral Tolerance: New Insights and Prospects for Clinical...
- Magazine article from: SciTech Book News June 1, 2005 700+ words
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