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Nasal immunization with heat shock proteins has therapeutic potential.
2002 DEC 11 - (NewsRx.com & NewsRx.net) -- Results of a study in mice suggest nasal immunization with heat shock proteins could be a new approach to treating atherosclerosis.
According to researchers, "Increasing evidence supports the involvement of inflammation and immunity in atherogenesis as well as the role of autoimmunity to heat shock proteins (HSPs) in the progression of atherosclerosis. Mucosal administration of autoantigens decreases organ-specific inflammation and disease in several models of autoimmunity (diabetes, arthritis, and encephalomyelitis) and is also being tested in human clinical trials."
R. Maron and colleagues, Brigham and Women's Hospital, Boston, Massachusetts, "examined the effect of nasal or oral administration of mycobacterial HSP-65 on atherosclerotic lesion formation in mice lacking the receptor for LDL [low density lipoprotein] that were maintained on a high-cholesterol diet." They reported their findings in the journal Circulation.
"Animals were nasally or orally treated for 1 week with HSP-65, and a high-cholesterol diet was started after the last treatment. The mice were mucosally treated once a week for 8 or 12 weeks, at which time pathological analysis was performed," wrote Maron and coauthors (Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation, ...
- A raison d'etre for heat-shock proteins.
- Magazine article from: Science News Vaughan, Christopher May 7, 1988 700+ words
A raison d'etre for heat-shock proteins Cells of all organisms respond to heat...stresses by making complex molecules called heat-shock proteins. Ohter heat-shock proteins exist in unstressed cells and seem to play...
- Hot-shot proteins: new drugs. (heat shock proteins are being researched to see...
- Magazine article from: The Economist (US) April 18, 1998 700+ words
...which they can sell for it. And among their most promising booty is a class of molecules known as heat shock proteins (HSPs). Heat shock proteins are there to keep other proteins in shape-literally. All proteins consist of chains of chemical...
- Stressgen obtains new European patent for heat shock protein fusions.(European...
- Newspaper article from: BIOTECH Patent News January 1, 2002 700+ words
...using fusion proteins comprised of heat shock proteins fused to antigens. Stressgen...0900). Using this patented heat shock protein 'fusion' technology...patent received this month on our heat shock protein 'fusion' technology...
- Heat shock proteins; new research.(Brief article)(Book review)
- Magazine article from: SciTech Book News March 1, 2009 700+ words
9781604566413 Heat shock proteins; new research. Ed. by Emma...new research in the field of heat shock proteins (HSP), groups of proteins...audience. A sampling of topics: heat shock proteins as possible anti-HIV agents...
- Stressgen announces issuance of U.S. patent solidifying its heat shock...
- Press release article from: PR Newswire January 4, 2002 700+ words
...market a compound such as our heat shock protein fusion candidate, HspE7...excited that the discovery of heat shock proteins and fusions as powerful stimulants...research studies to evaluate its heat shock protein 'fusion' technology...
- Nature's remedy for stressed-out plants. (heat-shock proteins found in field...
- Magazine article from: Science News January 6, 1996 700+ words
...generate hardy molecules called heat shock proteins that not only resist stress...for example, the genes for heat shock proteins turn on, churning out the...until the stress subsides. Heat shock proteins appear to work by binding to...
- Heat shock proteins protect retina.
- Press release article from: PR Newswire September 29, 1988 700+ words
...M., SEPT. 29, 1988/ HEAT SHOCK PROTEINS PROTECT RETINA /ADVANCE...Sept. 29 /PRNewswire/ -- Heat-shock proteins, part of the body's natural...retinal synthesis of three heat-shock proteins when rats were exposed to...
- Heat shock proteins for immunotherapy of rheumatoid arthritis reviewed.
- Magazine article from: Women's Health Weekly January 22, 2004 700+ words
...Researchers review the use of heat shock proteins for immunotherapy of rheumatoid...bacterial and human derived heat shock protein peptides." Yung and...study in Inflammation Research (Heat shock proteins (HSP) for immunotherapy of...
Source: HighBeam Research, Nasal immunization with heat shock proteins has therapeutic potential.