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2002 DEC 11 - (NewsRx.com & NewsRx.net) -- Among bacillus Calmette-Guerin (BCG)-vaccinated children, those with allergies mount a higher response to tuberculin than those who are nonallergic, a recent study found.
"The prevalence of allergic disorders has been increasing over the last 30 years, especially in developed countries. One factor associated with this rise may be the decline of many childhood infections," said S. Ozmen and colleagues.
These researchers conducted a study of "tuberculin responses in allergic children in order to see the development of delayed-type hypersensitivity reactions to tubercule bacillus infection."
The researchers measured wheal size in 106 allergic and 100 nonallergic BCG-vaccinated children to whom the Mantoux test had been administered.
"The wheal size was 6.29 [+ or -] 5.09 mm (mean [+ or -] SD) in allergic children, and 2.79 [+ or -] 2.96 mm in nonallergic children. The difference between the two groups was significant (p
"In children with a single BCG scar, the mean purified protein derivative (PPD) wheal size for allergic children was 4.77 [+ or -] 4.79 mm, and for nonallergic children it was 2.48 [+ or -] 3.19 mm," the researchers found. Among children vaccinated twice, mean ...