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Cozaar. (News & Approved).
(losartan, Merck)
An angiotensin receptor blocker (ARB) for treating diabetic nephropathy with an elevated serum creatine and proteinuria in patients with type 2 diabetes and a history of hypertension. Cozaar and Avapro (irbesartan) are the first ARBs approved for this indication. (Avapro will be reviewed here in December.) Previously approved for hypertension.
Recommended Dosage: Starting at 50 mg once daily, increasing to 100 mg once daily based on blood pressure response.
Special Considerations: In a study of 1,513 patients with type 2 diabetes and advanced nephropathy that led to the approval, adverse events were similar with placebo and Cozaar. Side effects reported more often in Cozaar-treated patients included hypotension (7% vs. 3%).
Comment: In the study the risks of a doubling of the serum creatinine and of endstage renal disease (ESRD) were reduced by 25% and 28%, respectively among those on Cozaar vs. placebo; the benefits were "beyond that attributable to blood pressure control" (N. Engl. J. Med. 345[12]861-69, 2001). There was no impact on ...
- FDA Approves Cozaar to Reduce the Rate of Progression of Nephropathy in Type 2...
- Press release article from: Business Wire September 19, 2002 700+ words
...effect on overall mortality. Cozaar is the only medicine that...This new indication for Cozaar may help physicians better...2 diabetic patients, the American Diabetes Association guidelines support...1994 and 1998. Once-daily Cozaar demonstrated renal benefits...
- FDA gives Cozaar new indication. (Diabetes Care).(medication can be used to...
- Magazine article from: Chain Drug Review October 28, 2002 700+ words
...This new indication for Cozaar may help physicians better...we lower blood pressure." Cozaar is an angiotensin II receptor...hypertensive Type 2 diabetes patients American Diabetes Association guidelines support...first-line therapy. Like Cozaar, Avapro's new indication...
- Merck's Cozaar(R) cleared for marketing by FDA first in new class of blood...
- Press release article from: Business Wire April 18, 1995 700+ words
...BUSINESS WIRE)--April 18, 1995--Cozaar (losartan potassium tablets), a once...amp; Co. Inc., announced Tuesday. Cozaar is the first in a new class of effective...Angiotensin-II (A-II) receptor blockers. Cozaar lowers high blood pressure by blocking...
- Cozaar(R) Significantly Reduced Progression of Kidney Disease in Patients with...
- Press release article from: PR Newswire May 19, 2001 700+ words
...disease, investigational treatment with Cozaar(R) (losartan potassium tablets...the American Society of Hypertension. Cozaar, from Merck & Co., Inc. (NYSE...investigate the renal protective effect of Cozaar in patients with Type 2 diabetes and kidney...
- FDA Approves COZAAR as the First and Only Hypertension Medicine to Help Prevent...
- Press release article from: Business Wire March 25, 2003 700+ words
...the landmark LIFE trial, once daily COZAAR significantly reduced the risk of stroke...indication for Merck's antihypertensive drug COZAAR(R) (losartan potassium tablets). The new label states that COZAAR is indicated to reduce the risk of stroke...
- Results of Trial with COZAAR in Patients with Acute Myocardial Infarction...
- Press release article from: Business Wire September 2, 2002 700+ words
...Results of a large clinical trial comparing COZAAR(R) (losartan potassium tablets) to...OPTIMAAL) -- was designed to determine if COZAAR would be either superior or non-inferior...trial were randomized to treatment with COZAAR or captopril within 10 days of experiencing...
- FDA Advisory Committee Recommends Approval of a New Indication for COZAAR-R-...
- Press release article from: Business Wire January 6, 2003 700+ words
...recommended approval of a new indication for COZAAR (losartan potassium tablets), Merck...precautionary language in labeling for COZAAR regarding the results of the LIFE study...investigational use of a regimen containing COZAAR significantly reduced the primary composite...
- HYZAAR(R) 100-12.5 mg Offers A New Convenient Dosing Option Within The Losartan...
- Press release article from: Business Wire October 21, 2005 700+ words
...combines the once-daily efficacy of 100 mg COZAAR(R) (losartan potassium tablets) with...pressure is not adequately controlled by COZAAR 100 mg. HYZAAR 100-12.5 mg, now...prescription only and is priced the same as COZAAR 100 mg. HYZAAR is also indicated to reduce...