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Enzyme produced by bacteriophage can destroy anthrax bacteria. (Studies in Humans Planned).

Internal Medicine News

| November 15, 2002 | Splete, Heidi | COPYRIGHT 2002 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

A protein made by an anthrax-specific bacteriophage kills the bacteria by destroying the cell walls, researchers from Rockefeller University, New York City said in a letter to Nature.

Raymond Schuch, Ph.D., Daniel Nelson, Ph.D., and Vincent A. Fischetti, Ph.D., described the enzyme PlyG as the jump-starter that causes bacteriophages specific to Bacillus anthracis to rupture and destroy the bacteria (Nature 418[6900]:884-89, 2002).

Anthrax bacteria seem unable to develop resistance to this lysine-based attack. "Lysins are highly evolved enzymes, modified and improved for high activity and specificity over millennia," they said. The PlyG lysin also may have treatment value. About 70% (13 of 19) of mice infected with Bacillus cereus (a close relative of anthrax) survived when given PlyG 15 minutes after infection.

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