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Higher antiplatelet dose. (Clinical Capsules).
Among patients about to undergo percutaneous coronary intervention (PCI), those with the most severe angina may be somewhat resistant to antiplatelet pretreatment and may require doses much higher than standard to ward off complications, said Dr. Daniel Soffer of William Beaumont Hospital, Royal Oak, Mich., and his associates.
Recent data suggested that a high pre-procedure loading dose (450 mg) of clopidogrel would achieve greater platelet inhibition and would act more rapidly than the standard 300-mg loading dose in patients undergoing PCI for angina. But platelet function studies were not performed, and the impact of angina class on the degree of platelet ...
- INTEGRILIN(R) (Eptifibatide) Injection When Added to Clopidogrel Provided...
- Press release article from: PR Newswire March 1, 2005 700+ words
...alone in providing platelet inhibition in PCI. CLEAR...adequate and sustained platelet inhibition in preventing heart...The relation of platelet inhibition to heart muscle...coronary syndrome (unstable angina/non-ST-segment...
- Addition of INTEGRILIN provides superior platelet inhibition with stenting.
- Newspaper article from: Science Letter December 7, 2004 700+ words
...that potent early platelet inhibition with INTEGRILIN...achieving adequate platelet inhibition and preventing...the relation of platelet inhibition to heart muscle...coronary syndrome (unstable angina/non-ST-segment...
- New Clinical Trial Data Showed the Addition of INTEGRILIN(R) (Eptifibatide)...
- Press release article from: PR Newswire November 8, 2004 700+ words
...that potent early platelet inhibition with INTEGRILIN...achieving adequate platelet inhibition and preventing...the relation of platelet inhibition to heart muscle...coronary syndrome (unstable angina/non-ST-segment...
- Results of Early Data Show More Consistent Platelet Inhibition with Prasugrel...
- Press release article from: PR Newswire March 9, 2005 700+ words
...greater level of platelet inhibition could have important...heart attack or unstable angina (heart- related...this level of platelet inhibition (p less than...maximum level of platelet inhibition was greater for...
- Early-Phase Data Show Prasugrel Demonstrates More Consistent Platelet...
- Press release article from: PR Newswire October 17, 2005 700+ words
...heart attack or unstable angina (heart-related...represent levels of platelet inhibition that are more consistent...heart attack or have unstable angina and are to undergo...heart attacks and unstable angina, called acute coronary...
- Study Shows More Potent and More Reliable Platelet Inhibition with Prasugrel...
- Press release article from: PR Newswire March 14, 2006 700+ words
...developing prasugrel, an oral antiplatelet agent, as a potential treatment for patients who have suffered a heart attack or unstable angina (heart-related chest pain). Antiplatelet agents are used both acutely and as maintenance therapy to inhibit platelet...
- Study Suggests That Higher Loading Doses of Plavix Provides Quicker Onset of...
- Press release article from: PR Newswire May 24, 2005 700+ words
...loading doses of Plavix(R): 300mg, 600mg and 900mg. The study enrolled a total of 103 patients aged 18 to 85 years with unstable angina or non-ST-segment elevation myocardial infarction within the 48 hours prior to randomisation. Patients having received...
- Bypass Surgery vs. Stenting for Multivessel Disease in Stable and Unstable...
- Magazine article from: Clinical Cardiology Alert July 1, 2002 700+ words
...Multivessel Disease in Stable and Unstable Angina This is a relatively small randomized...surgery in individuals with stable and unstable angina with multivessel coronary disease...that revascularization results in unstable angina are less favorable than in those who...
