AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Phase II trial of Navelbine plus Herceptin for HER2 looks promising.
2002 DEC 5 - (NewsRx.com & NewsRx.net) -- New research suggests that the combination of Navelbine (vinorelbine tartrate) Injection, a first-line chemotherapy treatment for advanced non-small cell lung cancer, and the monoclonal antibody therapy Heceptin (trastuzumab) is a promising and generally well tolerated treatment for HER2 positive metastatic breast cancer and warrants further study
Navelbine is not currently indicated for use in women with metastatic breast cancer.
The multicenter open-label trial enrolled 40 women with metastatic disease (spread to sites in the body beyond the breast) whose tumors over-expressed the HER2Neu oncogene, a growth-promoting protein that has been closely linked to a poor prognosis in breast cancer, and were therefore candidates for Herceptin therapy. The study was designed to determine if the addition of Navelbine would increase the expected response rate to Herceptin therapy without significantly increasing serious side effects.
Mohammad Jahanzeb, MD, chief, division of hematology/oncology at the University of Tennessee College of Medicine, led the group of investigators from seven cancer centers across the United States.
Weekly intravenous doses of Herceptin and Navelbine were administered over 4-week courses. Thirty-seven patients were evaluated for a response after receiving at least two courses. ...
- Complete Results of Phase II Trial of Navelbine plus Herceptin for Her2...
- Press release article from: PR Newswire October 28, 2002 700+ words
...positive metastatic breast cancer and warrants further study.(1) Navelbine is not currently...with metastatic breast cancer. The multi...treatment of advanced breast cancer, either as a...with Herceptin. Navelbine Injection is indicated...
- UK's NICE gives guidance on Pierre Fabre's Navelbine for advanced breast cancer.
- Newspaper article from: Pharma Marketletter December 23, 2002 700+ words
...Pierre Fabre's Navelbine (vinorelbine...treatment of advanced breast cancer on National Health...for advanced breast cancer, however it...routine use of Navelbine with other drug...with advanced breast cancer," and will...
- WELLCOME'S NAVELBINE RECOMMENDED AS TREATMENT FOR ADVANCED NON-SMALL CELL LUNG...
- Press release article from: PR Newswire December 15, 1993 700+ words
...cancers and has surpassed breast cancer as the leading cause...The availability of Navelbine," said Richard Gralla...trials underway to study Navelbine as a potential therapy...other cancers including breast cancer and ovarian cancer...adverse experiences with Navelbine were ...
- ANX-530 Demonstrates Equivalent Pharmacokinetics to Navelbine(R) in a...
- Press release article from: PR Newswire April 15, 2008 700+ words
...site reactions attributed to Navelbine was consistent with its product...chemotherapy drug vinorelbine. Navelbine, a branded formulation of...and advanced or metastatic breast cancer. Worldwide sales of Navelbine and generic formulations of...
- Study shows Navelbine boosts Herceptin response without increasing side effects.
- Newspaper article from: Drug Week November 29, 2002 700+ words
...combination of Navelbine injection and...positive metastatic breast cancer. The complete...positive metastatic breast cancer, with a median...Herceptin and Navelbine as first-line...in metastatic breast cancer for women with...
- Study shows Navelbine boosts Herceptin response without increasing side...
- Newspaper article from: Cancer Weekly November 26, 2002 700+ words
...combination of Navelbine injection and...positive metastatic breast cancer. The complete...positive metastatic breast cancer, with a median...Herceptin and Navelbine as first-line...in metastatic breast cancer for women with...
- Phase II trial of Navelbine plus Herceptin for HER2 looks promising.
- Newspaper article from: Angiogenesis Weekly December 6, 2002 700+ words
...positive metastatic breast cancer and warrants further study Navelbine is not currently...with metastatic breast cancer. The multicenter...poor prognosis in breast cancer, and were therefore...the addition of Navelbine would increase...
- First Success From SD Pharma Takeover Adventrx's Emulsion Navelbine Found...
- Magazine article from: BIOWORLD Today Osborne, Randall November 19, 2007 700+ words
...alone or with cisplatin, Navelbine and its generic versions sold...25, then ANX-530 and Navelbine were considered equivalent...patients got either ANX-530 or Navelbine. After a "washout" period...Phase II trial with 5-FU in breast cancer, but a Phase III trial with...
Source: HighBeam Research, Phase II trial of Navelbine plus Herceptin for HER2 looks promising.