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Angiopoietin 1 promotes tumor angiogenesis, tumor vessel plasticity in mice.
2002 DEC 5 - (NewsRx.com & NewsRx.net) -- Using a murine model of cervical cancer, researchers in Singapore have shown that increased expression of angiopoietin 1 boosts tumor angiogenesis and leads to tumor vessel plasticity.
"Angiopoietins have been increasingly implicated to play important roles in blood vessel formation, remodeling, maturation, and maintenance. However, their roles in tumor angiogenesis and hence tumor growth and metastasis still remain uncertain," wrote W.S.N. Shim and colleagues, National University Singapore.
They reported that "angiopoietin 1 expression was amplified in human cervical cancer HeLa cells by stable transfection or recombinant human adenovirus-mediated gene transfer."
"We show that increased angiopoietin 1 expression promoted in vivo growth of human cervical cancers in mice by promoting tumor angiogenesis and inhibiting tumor cell apoptosis. Furthermore, we also show for the first time that overexpression of angiopoietin 1 also leads to increased tumor vessel plasticity ...
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