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Candida-specific IgA antibodies may have limited natural protective activity.
2002 DEC 5 - (NewsRx.com & NewsRx.net) -- A recent study investigated the role of humoral immunity induced by Candida albicans infection in protection against experimental vaginal candidiasis.
"Protective host defense mechanisms against vaginal Candida albicans infections are poorly understood," noted K.L. Wozniak and colleagues at Louisiana State University's Health Science Center. "Although cell-mediated immunity (CMI) is the predominant host defense mechanism against most mucosal Candida infections, the role of CMI against vaginal candidiasis is uncertain, both in humans and in an experimental mouse model. The role of humoral immunity is equally unclear."
They continued: "While clinical observations suggest a minimal role for antibodies against vaginal candidiasis, an experimental rat model has provided evidence for a protective role for Candida-specific immunoglobulin A (IgA) antibodies. Additionally, Candida vaccination-induced IgM and IgG3 antibodies are protective in a mouse model of vaginitis."
Wozniak's group assessed how infection-induced humoral immunity plays a protective part against vaginal candidiasis by measuring the levels of "Candida-specific IgA, IgG, and IgM antibodies in serum and vaginal lavage fluids of mice with primary and secondary (partially protected) infection."
The researchers reported that "[i]n naive mice, total, but not Candida-specific, antibodies were detected in serum and lavage fluids, consistent with lack of yeast colonization in mice. In infected mice, Candida-specific IgA and IgG antibodies were induced in serum with anamnestic responses to secondary infection."
"In lavage fluid, while Candida-specific ...
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Source: HighBeam Research, Candida-specific IgA antibodies may have limited natural protective...