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Tamoxifen boosts antiangiogenic therapy in murine model.(breast cancer)
2002 DEC 5 - (NewsRx.com & NewsRx.net) -- Synergistic activity of an antiestrogen drug combined with an angiogenesis inhibitor reduced tumor growth in a study of human breast cancer conducted in mice.
The researchers who conducted the work think the finding may prove applicable to treatment in humans.
"Breast tumor growth and metastasization are both hormone-sensitive and angiogenesis-dependent. Recent work carried out in our laboratory on a transgenic model of breast cancer displaying many similarities to its human counterpart has shown that liposome-mediated angiostatin cDNA delivery partially inhibits both local and metastatic growth," wrote M.G. Sacco and colleagues.
"However," they went on to say, "it is now recognized that anti-angiogenesis strategy alone cannot completely arrest tumor growth and spread, and this led to the suggestion that approaches based on different molecular mechanisms could usefully be combined."
Sacco's team conducted a study to determine "whether tamoxifen, a classical anti-estrogen agent widely used in human therapy, could improve the results obtained with angiostatin alone."
They reported that "[f]urther reduction of local growth was achieved with the combined regimen with respect to angiostatin or ...
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Source: HighBeam Research, Tamoxifen boosts antiangiogenic therapy in murine model.(breast...