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Reduced risk associated with prior use of hormone therapy.(Alzheimer disease)
2002 DEC 5 - (NewsRx.com & NewsRx.net) -- A relationship between prior use of hormone replacement therapy (HRT) and a reduced risk of Alzheimer disease (AD) in older women is reported by researchers in a study in the Journal of the American Medical Association.
Peter P. Zandi, PhD, of Johns Hopkins University, Baltimore, and investigators from the Cache County Study, analyzed data on the association between use of HRT and the risk of AD in elderly women. "Compared with men, women appear to be at increased risk of Alzheimer disease (AD) after ages 80 to 85 years," the authors wrote in background information for the article.
They suggested that postmenopausal depletion of endogenous estrogens may contribute to this risk but pointed out that previous studies examining the relationship between HRT and AD have provided mixed results.
The Cache County Study is a long-term investigation of the prevalence and incidence of AD and other dementias in relation to genetic and environmental risk factors. The new analyses considered 1357 men (mean age, 73.2 years) and 1889 women (mean age, 74.5 years) residing in the Utah county. These individuals were first assessed in 1995-1997, and underwent follow-up studies in 1998-2000. At the initial contact, the investigators gathered a history of women's current and former use of HRT, as well as of calcium and multivitamin supplements.
The researchers found that 35 men (2.6%) and 88 women (4.7%) developed AD between the initial interview and time of follow-up 3 years later. Women who used HRT had a 41% reduction in their risk of AD (26 cases among 1066 women) compared with non-HRT users (58 cases among 800 women).
"We observed a distinct relation between AD risk and duration of HRT use," the authors wrote. They described "considerably stronger effects with longer duration of usage. Compared with nonusers, Cache County women who had used HRT for more than 10 years experienced 2.5-fold lower incidence, comparable with the risk observed in men. A new finding in this study is an apparent limited window of time during which sustained HRT exposure seems to reduce the risk of AD. We found that, in contrast with earlier use, HRT exposures within 10 years of AD onset yielded little, if any, apparently benefit."
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Source: HighBeam Research, Reduced risk associated with prior use of hormone therapy.(Alzheimer...