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Study of pneumococcal proteins supports exploration of mucosal immunization.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- Results of a study from England support earlier work in mice that suggests pneumococcal proteins may have potential as vaccine candidates against pneumococcal infection.
Q.B. Zhang and colleagues, University of Bristol, Avon, UK, conducted a study to see if the pneumococcal proteins PspA, pneumolysin, PsaA, and CbpA might be good mucosal immunogens in humans.
They used ELISpot assay to test adenoidal lymphocytes from 20 children for antigen-specific antibody-secreting cells (ASCs). "Cells were also cultured for 7 days in the presence of a concentrated culture supernatant (CCS) from a type 14 strain of Pneumococcus which contained secreted pneumococcal proteins, including PspA, pneumolysin, PsaA, and CbpA, and then tested by ELISpot.
"ELISpot assays done on freshly isolated cells detected ASCs to all four antigens in most children studied," Zhang and coauthors reported. "However, there were differences both between antigens and between isotypes." Among these:
* "The densities of immunoglobulin G (IgG) ASCs against both PsaA and CbpA were significantly higher than those of ASCs for PspA and PdB (pneumolysin toxoid B) (p
* "For all antigens, the numbers of IgA ASCs tended to be lower than those of both IgG and IgM ASCs."
* "The numbers of anti-CbpA and -PsaA IgA ASCs were higher than those of anti-PdB IgA ASCs (p
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Source: HighBeam Research, Study of pneumococcal proteins supports exploration of mucosal...