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Oral vaccine induces specific circulating mucosa-homing T cells.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- Muscosal immunization via a live, oral, bacterial vaccine has been shown by researchers in Sweden to induce antigen-specific CD4+ and CD8+ memory T cells, "almost all of which express the gut-homing integrin beta(7)," they say.
According to B.S. Lundin and colleagues, Gothenburg University, "The kinetics and homing characteristics of T-cell responses in humans after mucosal immunizations have not been well characterized. Therefore, we have investigated the magnitude and duration of such responses as well as the homing receptor expression of antigen-specific peripheral blood T cells by using an oral model vaccine, i.e, the live, attenuated Salmonella enterica serovar Typhi [S. typhi] vaccine (Ty21a)."
The study involved eight volunteer subjects each given three doses of the S. enterica vaccine 2 days apart. CD4+ and CD8+ T cells were separated via magnetic beads from blood samples that were taken from the subjects before they were vaccinated and "at regular intervals thereafter."
"To purify the potentially antigen-specific gut-homing T cells, CD45RA- integrin W cells were further sorted by flow cytometry. The sorted cells were then stimulated in vitro with the serovar Typhi vaccine strain, and the proliferation of cells and the cytokine production were measured," the researchers explained.
Lundin's group reported that "[f]ollowing vaccination, there was a large increase in both the proliferation of and the gamma interferon (IFN-gamma) production by blood T cells stimulated with the vaccine strain. The responses were seen ...
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Source: HighBeam Research, Oral vaccine induces specific circulating mucosa-homing T cells.