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Virus-like particles do not activate Langerhans cells.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- Langerhans cells are not activated by human papillomavirus (HPV) virus-like particles, report cancer researchers, who say this suggests a possible "immune escape mechanism" used by HPV.
"High-risk human papillomaviruses are linked to several malignancies including cervical cancer. Because human papillomavirus-infected women do not always mount protective antiviral immunity, we explored the interaction of human papillomavirus with Langerhans cells, which would be the first APCs [antigen-presenting cells] the virus comes into contact with during infection," stated S.C. Fausch and colleagues, Loyola University, Cardinal Bernardin Cancer Center.
The authors added, "We determined that dendritic cells, normally targeted by vaccination procedures and Langerhans cells, normally targeted by the natural virus equally internalize human papillomavirus virus-like particles."
"However," the researchers noted, "in contrast to dendritic cells, Langerhans cells are not activated by human papillomavirus virus-like particles, illustrated by the lack of: up-regulating activation markers, secreting IL-12, stimulating T cells in an MLR, inducing human papillomavirus-specific immunity, and ...
- Virus-like particles do not activate Langerhans cells.(human papillomavirus)
- Magazine article from: Women's Health Weekly December 5, 2002 700+ words
...net) -- Langerhans cells are not activated by human papillomavirus (HPV) virus...interaction of human papillomavirus with Langerhans cells, which would...dendritic cells, Langerhans cells are not activated by human papillomavirus virus-like...
- Virus-like particles do not activate Langerhans cells.(Brief Article)
- Newspaper article from: Virus Weekly December 3, 2002 700+ words
...net) -- Langerhans cells are not activated by human papillomavirus (HPV) virus...interaction of human papillomavirus with Langerhans cells, which would...dendritic cells, Langerhans cells are not activated by human papillomavirus virus-like...
- HPV16's E6 downregulates cell surface E-cadherin, reducing Langerhans cells.
- Newspaper article from: Virus Weekly September 23, 2003 700+ words
...the Journal of Virology, "Human papillomavirus type 16 (HPV16) is an oncogenic...response. Intraepithelial Langerhans cells (LC) are antigen-presenting...Depletion of Langerhans cells in human papillomavirus type 16-infected skin is...
- Dendritic cells and Langerhans cells both cross-prime T cells.
- Newspaper article from: Vaccine Weekly September 8, 2004 700+ words
...cells and Langerhans cells in the mechanism...Australia, "As human papillomavirus-like particles...DC) and Langerhans cells (LC) have...cells and Langerhans cells in the mechanism...areas of Human Papillomavirus Vaccine...
- Evaluation of Langerhans' Cells in the Cervical Epithelium of Women with CIN.
- Magazine article from: OB/GYN Clinical Alert December 1, 1999 700+ words
Evaluation of Langerhans Cells in the Cervical Epithelium of Women with CIN Abstract &...75: 130-135. For some time it has been known that both human papillomavirus (HPV) infection and high-grade cervical intraephithelial...
- Langerhans Cells Express Functional CXCR4.(Brief Article)
- Newspaper article from: AIDS Weekly October 8, 2001 700+ words
...Greer, senior medical writer - Human Langerhans cells express a functional HIV coreceptor...epithelium of genital mucosae via Langerhans cells," explained Prof. Christian Genin...cultured but not freshly isolated Langerhans cells has been described." Genin and research...
- Cored tubules are present in human epidermal Langerhans cells.
- Newspaper article from: Immunotherapy Weekly April 30, 2003 700+ words
...tubules are present in human epidermal Langerhans cells and may be part of the early recycling...interestingly not found in murine epidermal Langerhans cells. In this work we demonstrate that...in freshly isolated human epidermal Langerhans cells. "The tubules were found to be ...
- Tenofovir provides superior protection for dendritic, Langerhans cells.
- Newspaper article from: Drug Week January 31, 2003 700+ words
...to recent research from Belgium, "Langerhans cells and interstitial dendritic cells are...dendritic cells (MO-DC), MO-derived Langerhans cells (MO-LC), PHA/IL-2-activated...of HIV replication in dendritic/Langerhans cells, the first-line cell types targeted...
