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NK cell activity is dominated by US2-11-mediated HLA class I down-regulation.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- "A highly attractive approach to investigate the influence and hierarchical organization of viral proteins on cellular immune responses is to employ mutant viruses carrying deletions of various virus-encoded, immune-modulating genes," said researchers in Germany, who followed just such a strategy in studying cellular immunity and the human cytomegalovirus (CMV).
In their work, the University of Munich virologists used "a novel set of deletion mutants of the human CMV (HCMV) lacking the UL40 region either alone or on the background of a deletion mutant devoid of the entire US2-11 region.
C.S. Falk and colleagues reported that "[d]eletion of UL40 had no significant effect on lysis of infected cells by NK [natural killer] cells, indicating that the expected enhancement of HLA-E expression by specific peptides derived from HCMV-encoded gpUL40 leader sequences was insufficient to confer target cell protection.
"Moreover, the kinetics of MHC class I down-regulation by US2-11 genes observed at early and late phases postinfection with wild-type virus correlated with increased susceptibility to NK lysis."
"Thus," they continued, "the influence of HCMV genes on NK reactivity follows a hierarchy ...
- NK cell activity is dominated by US2-11-mediated HLA class I...
- Newspaper article from: Virus Weekly December 3, 2002 700+ words
...Falk and colleagues published their study in Journal of Immunology (NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation. J Immunol, 2002;169(6):3257-3266). The...
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...Netherlands, "Human leukocyte antigen (HLA) class I molecules are expressed on the surface...We previously reported that loss of HLA class I expression in diffuse large B-cell...and mutations of the light chain of the HLA class I molecule, beta(2)-microglobulin...
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"Immunogenic HLA Class I Bound Peptides Derived from dbl Protooneogene...immunization of PBMC from sharing an HLA Class I restriction element with U937 cells...both cells. Such peptides, bound to HLA-Class I molecules, mav represent effective...
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Source: HighBeam Research, NK cell activity is dominated by US2-11-mediated HLA class I...