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Passive immunization against beta-amyloid peptide protects CNS neurons.(central nervous system)
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- A study by researchers in Switzerland suggests that passive immunization against beta-amyloid (Abeta) peptide may protect neurons from toxicity associated with Abeta.
M.H. Mohajeri and colleagues, University of Zurich, conducted a study in transgenic mice to "characterize the effects of the familial Alzheimer's disease-causing Swedish mutations of amyloid precursor protein (SwAPP) on the vulnerability of central nervous system neurons."
They caused the SwAPP-expressing mice to have epileptic seizures.
"The transgene expression did not change the seizure threshold, but consistently more neurons degenerated in brains of SwAPP mice as compared with wild-type littermates," reported the researchers. "The degenerating neurons were stained both by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling and by Gallyas silver impregnation."
"A susceptible population of neurons accumulated intracellular Abeta and immunoreacted with antibodies against activated caspase-3," they continued. "To demonstrate that increased Abeta levels mediated the increased vulnerability, we infused antibodies against Abeta and found a significant reduction in neuronal loss that was paralleled by decreased brain levels of Abeta. Because the SwAPP mice exhibited no amyloid plaques at the age of these experiments, transgenic ...
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...in Switzerland suggests that passive immunization against beta-amyloid (Abeta) peptide may protect neurons...seizures, and that lowering Abeta by passive immunization can protect neurons from Abeta-related toxicity." Mohajeri...
Source: HighBeam Research, Passive immunization against beta-amyloid peptide protects CNS...