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DNA vaccine inhibits autoimmune disease in rat model.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- Immunologists in Israel recently presented their work on DNA vaccination against adjuvant arthritis.
"Adjuvant arthritis (AA) is an autoimmune disease inducible in rats involving T-cell reactivity to the mycobacterial 65-kDa heat shock protein (HSP65). HSP65-specific T cells cross-reactive with the mammalian 60-kDa heat shock protein (HSP60) are thought to participate in the modulation of AA. In this work we studied the effects on AA of DNA vaccination using constructs coding for HSP65 (pHSP65) or human HSP60 (pHSP60)," explained F.J. Quintana and colleagues, Weizmann Institute of Science.
"We found that both constructs could inhibit AA but that pHSP60 was more effective than pHSP65," the researchers said.
"The immune effects associated with specific DNA-induced suppression of AA were complex and included enhanced T-cell proliferation to a variety of disease-associated Ags [antigens].
"Effective vaccination with HSP60 or HSP65 DNA led paradoxically to up-regulation of IFN-gamma secretion to HSP60 and, concomitantly, to down-regulation of IFN-gamma secretion to the P180-188 epitope of HSP65. There were also variable ...
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Source: HighBeam Research, DNA vaccine inhibits autoimmune disease in rat model.